University of Texas System

Baylor College of Medicine

Pulmotect, Inc.

Visiogen, Inc.

Scott E Evans

Michael J Tuvim

Burton F Dickey

Brenton Scott

Tuan Anh Nguyen

George Tsai

Brian E Gilbert

Ian Ayton

Margarita Martinez-Moczygemba

David P Huston

Magnus Hook

Diane Markesich

Phu H Nguyen

Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a StIR composition to the individual.

Compositions for stimulation of mammalian innate immune resistance to pathogens

Embodiments are directed to methods and compositions for modulating an immune response. In certain aspects the immune response is a type I hypersensitivity response. In particular aspects the subject has allergic asthma or allergic rhinitis. Using a conventional experimental asthma mouse model (BALB/c), the inventors demonstrate that aerosol administration of TLR agonists, in particular a combination of TLR2/6 and TLR9 agonist (e.g., TLR9 oligonucleotide agonist/PAM2CSK4) along with an antigen (e.g., ovalbumin (OVA)) suppresses the immune response as exemplified by the production of antigen-specific IgE and decreases the number of airway eosinophils in bronchoalveolar lavage fluid (BAL) in response to intraperitoneal (IP) immunization with an antigen mixed with alum.

Methods and compositions for adaptive immune modulation

Embodiments are directed to compositions and methods for treating viral infections.

Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds

Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a TLR9 agonist and a TLR 2/6 agonist to the individual.

Growing community of inventors

Bellaire, TX, United States of America

Scott E Evans