The United States of America, As Represented by the Secretary, Department of Health and Human Services

University System of Maryland

Scott Durum

Julie Hixon

Scott Walsh

Lila Kashi

Wen Qing Li

Joel Patrick Schneider

Yuji Yamada

Stephen Miller

Caroline Andrews

Steven Tau

Wenqing Li

Antibodies and antigen binding fragments that specifically bind to IL-7Rα are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7Rα using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7Rα, such as acute lymphoblastic leukemia.

Il-7R-alpha specific antibodies for treating acute lymphoblastic leukemia

This disclosure provides novel anionic amphiphilic &#x3b2;-hairpin peptides that self-assemble under appropriate conditions to form a reversible gel-sol hydrogel that can be used, for example, to readily deliver protein therapeutics and cells by injection to a target location in a subject.

Peptide hydrogels and use thereof

Antibodies and antigen binding fragments that specifically bind to IL-7R&#x3b1; are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7R&#x3b1; using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7R&#x3b1;, such as acute lymphoblastic leukemia.

IL-7R-alpha specific antibodies for treating acute lymphoblastic leukemia

Growing community of inventors

Frederick, MD, United States of America

Scott Durum