Advanced Solutions Life Sciences, LLC

University of Louisville Research Foundation, Inc.

Scott Douglas Cambron

Robert S Keynton

Kyle Eli

Daniel S Metzinger

Dakota Waldecker

John F Naber

Kevin M Walsh

Michael W Golway

Michael J Martin

Thomas Roussel

Hares A Patel

Dakota J Waldecker

Douglas J Jackson

Thomas J Roussel, Jr

Doug Jackson

Justin C Palmer

Richard Bernard Hageman, Iii

Suraj Alexander

Brandon Hanke

Julia W Abersold

Andrew Davis Blum

A trocar site closure clip includes a generally triangular central body, a pair of arms extending from the body, and an elongated support extending from the body between the arms. In use, the clip is advanced into a patient through a trocar, the trocar removed, then the clip partially retracted to engage and pierce the patient's tissue. The biodegradable clip remains in the patient's tissue, at least partially blocking the trocar site, and degrades over time as the patient heals.

Trocar site closure clip

A tiltable stage assembly includes a base and a tiltable stage operably coupled to the base and pivotable relative to the base. The tiltable stage is moveable between an initial position and a tilted position, wherein the tiltable stage is parallel with the base in the initial position and is oriented at an angle to the base when in the tilted position. The tiltable stage is biased to the initial position.

Tiltable stages and methods of using the same

A trocar site closure clip includes a generally triangular central body, a pair of arms extending from the body, and an elongated support extending from the body between the arms. In use, the clip is advanced into a patient through a trocar, the trocar removed, then the clip partially retracted to engage and pierce the patients tissue. The biodegradable clip remains in the patients tissue, at least partially blocking the trocar site, and degrades over time as the patient heals.

A method for operating the 3D printing tool includes positioning a first material distribution barrel within a first barrel orifice, where a first barrel tip is disposed at a first end of the first material distribution barrel. The method further includes positioning a second material distribution barrel within a second barrel orifice, where a second barrel tip is disposed at a first end of the second material distribution barrel. The method further includes dispensing building material from the first material distribution barrel when the first material distribution barrel is substantially vertically oriented and a second material distribution barrel is oriented at an angle from the vertical.

Tool for dispensing multiple materials with discrete positional control without need for sequential tool change

A 3D printer includes a multi-axis robot arm comprising a deposition end effector, a rotating adjustable print stage comprising a rotary unit and a mandrel, the rotating adjustable print stage configured to rotate the mandrel around a rotation axis, and a control unit. The control unit may be configured to move the robotic arm in a radial dimension and a longitudinal dimension with respect to the mandrel to position the deposition end effector with respect to the mandrel, rotate the mandrel with the rotary unit, and cause the deposition end effector to deposit constituent on the mandrel to form a 3D-printed construct.

Supplementary rotary axis for 3D printer

A temperature controlled dispensing tool includes a mount and a temperature controlled module coupled to the mount. The temperature controlled module may include a barrel housing, a barrel insert, one or more heating element, one or more cooling element, one or more temperature sensors, and a control unit. The barrel insert is removably insertable into the barrel housing and configured to receive a material barrel. The one or more heating elements and the one or more cooling elements are in thermal communication with the barrel insert. The control unit is configured to determine a temperature of the temperature controlled module based on the signal of the one or more temperature sensors, and selectively operate the one or more heating elements and the one or more cooling elements thereby controlling a temperature of the temperature controlled module.

Temperature controlled dispensing tools for three-dimensional printers

A storage assembly for storing a plurality of specimens includes a frame, a plurality of modular storage units for perfusion and/or incubation of one or more specimens removably coupled to the frame, a sample transfer apparatus configured to retrieve a specimen holder from a chosen modular storage unit of the plurality of modular storage units, and a control unit communicatively coupled to the sample transfer apparatus. The control unit is configured to cause the sample transfer apparatus to retrieve a specimen from a modular storage unit of the plurality of modular storage units and deliver the specimen to a delivery position.

Modular storage units for perfusion and/or incubation of one or more specimens and storage assemblies

A modular light for removably attaching to a bio-printer robot end effector, where the light includes: an annular modular light ring housing with an annular opening for receiving the end effector of the bioprinting robot; the housing substantially surrounding a dispensing tip of the end effector; a power supply interface to receive electrical power from the end effector; a plurality of LEDs positioned annularly around the end effector within the annular modular light ring housing, where the plurality of LEDs are spaced in at least two annular rows, where each of the at least two annular rows are at a unique elevational position within the annular modular light ring housing with respect to a light output plane of the annular modular light ring housing; the LEDs are in electrical communication with the power supply interface; and a controller communicatively coupled with the LEDs and the power supply interface.

Modular light source for curing of 3D printed biological and engineered materials

Methods and systems for 3D printing use a 3D printing device defined by a polar coordinate frame including an r-axis, a z-axis, and a rotational theta axis. The device includes a base, a rotatably attached printing stage is rotatably attached, a z-axis aligned pair of towers, an r-axis aligned rail slidably coupled to the towers, a print head slidably disposed on the rail, a printing tool coupling component ('master') joined to the print head, and a rotatable tool carousel with bays housing printing tools, each including a printing tool body ('slave'). The slave may be coupled with and locked to or unlocked from the master to form a coupled tool assembly through a mechanical actuation assembly. With the coupled tool assembly, a printing tool is removable from a respective bay when the coupled tool assembly moves along the r-axis in a direction opposite from the rotatable tool carousel.

Methods and systems for 3D printing with a 3D printing platform including printing tool coupling components

A 3D printing tool and assembly for dispensing multiple materials includes a barrel holder assembly having at least two barrel orifices extending from a top end of the barrel holder assembly through to a bottom end of the barrel holder assembly, where at least one of the at least two barrel orifices is oriented at an angle from the vertical. A method for operating the 3D printing tool includes positioning a first material distribution barrel within a first barrel orifice, where a first barrel tip is disposed at a first end of the first material distribution barrel. The method further includes dispensing building material from the first material distribution barrel when the first material distribution barrel is substantially vertically oriented and a second material distribution barrel is oriented at an angle from the vertical.

Systems and methods for a robotic fabrication and assembly platform providing a plurality of printable materials for fabrication of a three-dimensional object are provided. A method includes activating a pneumatic actuator to extend a quick-change turret from a pneumatic seal. The method may insert a plurality of barrels into the quick-change turret. The method may also align one of the plurality of barrels with a pneumatic seal in the quick-change turret. The method may also disengage the pneumatic actuator to seat the aligned barrel onto the pneumatic seal and print a three-dimensional object. The method may further halt the printing of the three-dimensional object prior to completion and engage the pneumatic actuator to extend the quick-change turret from the pneumatic seal.

System and method for a quick-change material turret in a robotic fabrication and assembly platform

An end effector calibration assembly includes an electronic controller, a first camera assembly communicatively coupled to the electronic controller, and a second camera assembly communicatively coupled to the electronic controller. A first image capture path of the first camera assembly intersects a second image capture path of the second camera assembly. The electronic controller receives image data from the first camera assembly, receives image data from the second camera assembly, and calibrates a position of the robot end effector based on the image data received from the first camera assembly and the second camera assembly.

End effector calibration assemblies, systems, and methods

Multi-component fluid mixing devices and methods of manufacturing and using such multi-component fluid mixing devices are provided. The multi-component fluid mixing devices include one or both of a serpentine flow path and an attachment point decoupled from an inlet of the multi-component fluid mixing devices. The method of use includes switching between multi-component fluid mixing devices with different length flow paths, while retaining a constant position of the outlet of the multi-component fluid mixing devices. A manufacturing method includes fusing two halves of a multi-component fluid mixing device together with mixing elements in a serpentine flow path captured in a mixer wall formed between the two halves of the multi-component fluid mixing device.

Growing community of inventors

Louisville, KY, United States of America

Scott Douglas Cambron