Intarcia Therapeutics, Inc.

Alza Corporation

I2o Therapeutics, Inc.

Scott D Lautenbach

Keith E Dionne

John R Peery

Jeremy C Wright

Judy A Magruder

Felix A Landrau

Pauline C Zamora

James B Eckenhoff

Michael A DesJardin

Pedro E De La Serna

Guohua Chen

Thomas R Alessi

Stan Lam

Rupal A Ayer

Michael A Desjardin

Scott D Jordan

Bonnie J Eckenhoff, Legal Representative

Steve A Berry

Craig I Rodenberger

Michael R Cole

James M Sellers

James B Eckenhoff, Deceased

Jay S Smith

Amy K Whitson

Lawton Hom

Matthew Weber

Devices, methods, and systems are provided for placing an implant into a patient and removing it therefrom.

Implant placement and removal systems

An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.

Osmotic delivery systems and piston assemblies for use therein

An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.

Two-piece, internal-channel osmotic delivery system flow modulator

The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.

Sustained delivery of an active agent using an implantable system

Growing community of inventors

San Mateo, CA, United States of America

Scott D Lautenbach