Merck + Co., Inc.

Scott D Feighner

Paul A Liberator

Helen Profous-Juchelka

Alex Elbrecht

Prasanta R Chakraborty

Michael Dashkevicz

Andrew D Howard

Leonardus H T Van Der Ploeg

Sheng-Shung Pong

Arthur A Patchett

Douglas J MacNeil

Doris F Cully

Roy G Smith

Carina P Tan

Joseph P Arena

Jack L Smith

Gino M Salituro

Karen Kulju McKee

Nancy N Tsou

James M Schaeffer

Lee-Yuh Pai

The motilin receptor has been isolated and cloned, and nucleic acid sequences are given. Two spice variants have been identified. Also, assays for motilin receptor ligands are given. The identification of the cloned motilin receptor may be used to screen and identify compounds which bind to the receptor for use in a variety of gastric conditions, including gastric motility disorders.

Cloning and identification of the motilin receptor

Human, swine and rat growth hormone secretagogue receptors have been isolated, cloned and sequenced. Growth hormone secretagogue receptors are new members of the G-protein family of receptors. The growth hormone secretagogue receptors may be used to screen and identify compounds which bind to the growth hormone secretagogue receptor. Such compounds may be used in the treatment of conditions which occur when there is a shortage of growth hormone, such as observed in growth hormone deficient children, elderly patients with musculoskeletal impairment and recovering from hip fracture and osteoporosis.

Growth hormone secretagogue receptor family

An assay for the detection of growth hormone secretagogue receptors and growth hormone secretagogue related receptors is described. As these receptors are a member of the G protein coupled receptors, a subunit of the G protein must be present in order for expression to be detected. A similar assay is described where the presence of growth hormone secretagogues are detected.

Assays for growth hormone secretagogue receptors

Unique species-specific Eimeria tenella DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria tenella.

Eimeria tenella 16S rDNA probes

Unique species-specific Eimeria praecox DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria praecox.

Eimeria praecox 16S rDNA probes

Unique species-specific Eimeria mitis DNA probes comprising divergent DNA sequences are disclosed. The probes ere complementary to a small subunit ribosomal RNA gene of Eimeria mitis.

Eimeria mitis 16S or DNA probes

Unguinol is a well-known metabolite of the fungi Aspergillus unguis and Aspergillus nidulans. Unguinol has been found to be an active growth permittant and promotant in animals, in particular, monogastric animals such as chickens. In addition, the fermentation broth also produced the additional known unguinol derivatives of folipastatin and 2-chloro unguinol as well as the novel 4-methyl derivative. All of these compounds are active animal growth permittants. Compositions containing such unguinol derivatives for use as growth permittants and promotants are also disclosed.

Unguinol and analogs are animal growth permittants

Unique species-specific Eimeria acervulina DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria acervulina.

Eimeria acervulina 16S rDNA probes

Unique species-specific Eimeria necatrix DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria necatrix.

Eimeria necatrix 16s rDNA probes

Unique species-specific Eimeria brunetti DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria brunetti.

Eimeria brunetti 16s rDNA probes

Unique species-specific Eimeria maxima DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria maxima.

Growing community of inventors

Scotch Plains, NJ, United States of America

Scott D Feighner