E.i. Dupont De Nemours and Company

Dupont US Holding, LLC

Scott D Cunningham

Hong Peng Wang

John P O'Brien

David J Lowe

Antoinette E Wilkins

Pierre E Rouviere

Stephen R Fahnestock

Robert DiCosimo

Mark Scott Payne

Tanja Maria Gruber

Steven Dale Ittel

Kari A Fosser

Linda Jane Solomon

Douglas Robert Anton

Sharon Loretta Haynie

Eberhard Schneider

Peter Wagner

Gregor Schurmann

Lisa A Butterick

Hong Wang

Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a variety of applications such as bleaching, whitening, disinfecting, destaining, deodorizing, and combinations thereof. Specifically, a fusion protein comprising a perhydrolytic enzyme and at least one peptidic component having affinity for a target surface (excluding body surfaces and oral care surfaces) is used in combination with a suitable substrate and a source of peroxygen to enzymatically produce a peracid on or near the surface of the target material. In a preferred aspect, the target surface is a cellulosic material.

Targeted perhydrolases

Disclosed herein are compositions and methods to treat an oral cavity surface with a peracid-based benefit agent. The peracid benefit agent can be use for oral surface bleaching, whitening, disinfecting, destaining, deodorizing, decreasing or removing biofilm, and combinations thereof. The peracid is enzymatically generated from a carboxylic acid ester substrate using a CE-7 carbohydrate esterase having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a peptidic component having affinity for an oral cavity surface, either directly or through an optional linker, may be used to target the perhydrolytic activity to the oral cavity surface.

Enzymatic peracid generation for use in oral care products

Peptide-based reagents comprising at least one tooth surface-binding peptide for delivery of at least one polymer-coated white colorant to the surface of teeth are provided. The peptide-based reagent may comprise at least one tooth-binding peptide coupled to, either directly or through one or more spacers, a polymer-binding peptide capable of binding to the polymeric coating on a polymer-coated white colorant. Methods of delivering a polymer-coated white colorant to a tooth surface are also provided as well as oral care compositions comprising the present peptide-based reagents. The peptide-based reagents may be used in conjunction with at least one polymer-coated white colorant to improve the cosmetic appearance of teeth.

Peptide-based tooth whitening reagents

Combinatorially generated peptides are provided that have binding affinity for polypropylene (PP). The peptides may be used to deliver benefit agents to various PP surfaces.

Polypropylene binding peptides and methods of use

Combinatorially generated peptides are provided that have binding affinity for polyethylene (PE). The peptides may be used to deliver benefit agents to various PE surfaces.

Polyethylene binding peptides and methods of use

Combinatorially generated peptides are provided that have binding affinity for polymethylmethacrylate (PMMA). The peptides may be used to deliver benefit agents to various PMMA surfaces.

PMMA binding peptides and methods of use

Combinatorially generated peptides are provided that have binding affinity for calcium carbonates. The peptides may be used to deliver benefit agents to various calcium carbonate surfaces.

Peptides for binding calcium carbonates and methods of use

Combinatorially generated peptides are provided that have binding affinity for clay. The peptides may be used to deliver benefit agents to various clay surfaces.

Clay-binding peptides and methods of use

Combinatorially generated peptides are provided that have binding affinity for nylon (NY). The peptides may be used to deliver benefit agents to various NY surfaces.

Nylon binding peptides and methods of use

Combinatorially generated peptides are provided that have binding affinity for Polytetrafluoroethylene (PTFE). The peptides may be used to deliver benefit agents to various PTFE surfaces.

Polytetrafluoroethylene binding peptides and methods of use

Combinatorially generated peptides are provided that have binding affinity for polystyrene (PS). The peptides may be used to deliver benefit agents to various PS surfaces.

Polystyrene binding peptides and methods of use

It has been found that Ambrosia sp. and Apocynum sp. accumulate lead in the leaves, stems, and roots when it grows in soil containing organic or inorganic species of lead. Lead is accumulated in the leaves and stems to a greater extent than in most other plants. Lead can be economically recovered from contaminated soil and sludge by harvesting Ambrosia sp. or Apocynum sp. grown in media containing high concentrations of lead.

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Chadds Ford, PA, United States of America

Scott D Cunningham