Emory University

Warsaw Orthopedic, Inc.

The United States Government As Represented by the Department of Veterans Affairs

Other

Warsaw Othopedic, Inc.

Medtronic Sofamor Danek

The US Govt As Represented by the Dept of Va

Scott D Boden

Sreedhara Sangadala

Jeffrey L Scifert

Neil B Beals

William F McKay

Gregory A Hair

Kathy Traianedes

Lawrence A Shimp

James S Marotta

Nelson L Scarborough

Randal R Betz

Albert Manrique

James L Russell

Jean T Edwards

John W Morris

Jeffrey C Marx

Nanette Forsyth

Christine Clark

F Louisa Titus

Susan J Drapeau

Todd M Boyce

Guobao Wei

Alexander R Vaccaro

Michael F O'Brien

Daryl R Sybert

Cristy Richards

Harvinder Sandhu

Munish Chandra Gupta

Robert Cohen

Sangwook Tim Yoon

Alexis P Shelokov

Stephen D Stamps

Neal Beals

Michael Boden

Frances Louisa Titus

Sangwook T (Tim) Yoon

This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker.

JAB1 inhibitory compositions for ossification and methods related thereto

The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement.

Compounds and compositions for ossification and methods related thereto

The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair and methods related thereto. In certain embodiments, the disclosure relates to compositions comprising one or more compound(s) disclosed herein, such as clotrimazole, honokiol, magnolol, tacrolimus, pimecrolimus, sirolimus, everolimus, temsirolimus, spironolactone, fluticasone, fluticasone propionate, fluticasone furoate, linezolid, telmisartan, chlorambucil, retinol, isotretinoin, acitretin, etretinate, retinoic acid (tretinoin), teniposide, mitomycin C, cytarabine, decitabine, vinblastine, vincristine, vindesine, vinorelbine, valrubicin, doxorubicin, daunorubicin, epirubicin, idarubicin, mitoxantrone, pixantrone, plicamycin, pazopanib, topotecan, camptothecin, irinotecan, sunitinib, derivatives, or salt thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement.

Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto

The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair, and methods related thereto. In certain embodiments, the disclosure relates to compositions comprising one or more compound(s) disclosed herein derivatives, or salt thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement. In certain embodiments, compounds disclosed herein are useful for managing obesity and diabetes or other metabolic syndromes by modulation of brown fat.

This disclosure relates to compounds and compositions for cartilage repair and methods related thereto. In certain embodiments, the disclosure relates to methods of inducing cartilage growth and regeneration comprising administering an effective amount of a composition comprising a compound disclosed herein to the subject or implanting a cartilage matrix comprising a compound disclosed herein in the subject. In certain embodiments, the compound is used locally such as injection at any desired site of cartilage formation.

TGF-beta enhancing compositions for cartilage repair and methods related thereto

An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.

Osteoimplant and method of making same

A method of repairing and/or treating bone is provided. The method includes implanting at a repair site an osteoimplant having a coherent aggregate of entangled elongate bone particles mixed with a biocompatible fluid carrier, the osteoimplant being flexible and further being formed as a strip at least one end of which possesses a tab for facilitating combination with another implant.

Osteoimplants and methods for their manufacture

Growing community of inventors

Atlanta, GA, United States of America

Scott D Boden