University of California

Cell Design Labs, Inc.

Scott Coyle

Wendell A Lim

Kole T Roybal

Peter Emtage

Russell Morrison Gordley

Stephen Santoro

Levi Rupp

The present disclosure provides synthetic modular polypeptide libraries and nucleic acids encoding such synthetic modular polypeptide libraries. Also provided are methods of making synthetic modular polypeptide libraries and nucleic acids encoding synthetic modular polypeptide libraries. Methods of screening a synthetic modular polypeptide library to identify a selected phenotype associated with a member of a synthetic modular polypeptide library are also provided where such methods find use in both in vitro and in vivo assays.

Modular polypeptide libraries and methods of making and using same

Methods and compositions are provided for reversibly localizing proteins to the exterior part of the cell surface. Compositions provided herein can include nucleic acids that encode polypeptides of interest and the ligand binding domain (LBD) of a nuclear hormone receptor. Medical applications are provided, including controlling the toxicity of CAR T cells.

Chimeric polypeptides and methods of altering the membrane localization of the same

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San Francisco, CA, United States of America

Scott Coyle