Ucb S.a.

Auckland Uniservices Limited

Darwin Molecular Corporation

Scott Charles Jeffrey

Neil S Cutshall

William Alexander Denny

J Jeffry Howbert

Graham John Atwell

Nathan C Ihle

Randy W Jackson

Jim P Boyce

Kraig M Yager

Ihab S Darwish

Theodore A Baughman

Dean Maeda

Shanjin Yang

The invention provides processes of preparing 3-substituted 1-(chloromethyl)- 1,2-dihydro-3H-[ring fused indol-5-yl(amine-derived)] compounds of formula (I) and its analogues, or a physiologically functional derivative thereof, (I), wherein A and B together may represent a fused optionally substituted benezene, naphthalene, pyridine, furan or a pyrrole ring, where the optional substituents are represented by Y; X is halogen or OSOR, and W is selected from NO, NHOH, N(R)NHR, NHCOR, N(phthaloyl) or NH, or W is further selected from the group (a), wherein J is selected from OH or H, and P is a group which is a substrate suitable for a nitroreductase or carboxypeptidase enzyme. The invention is also directed to the use of compounds of formula (I) prepared by the processes of the invention as cytotoxins for cancer therapy and as prodrugs for gene-directed enzyme-prodrug therapy (GDEPT) and antibody-directed enzyme-prodrug theraphy (ADEPT).

[object Object]

This invention is directed to compound of the following formula (I): wherein R, R, Rand Rare as described herein. These compounds and pharmaceutical compositions containing the compounds are useful in treating inflammatory disorders in mammals.

Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents

This invention is directed to methods of using a compound of the formula and pharmaceutically acceptable salts thereof, wherein n, X, Rand Rare disclosed herein, for treating inflammatory events in an animal subject.

Pharmaceutical uses and synthesis of nicotinamides

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Everett, WA, United States of America

Scott Charles Jeffrey