Metavention, Inc.

Signum Biosciences, Inc.

Medtronic Ireland Manufacturing Unlimited Company

Princeton University

Scott Bradley Vafai

Bobak Robert Azamian

Jonathan A Coe

Jeffry B Stock

Maxwell Stock

Michael Voronkov

Haoming Gu

Scott Raymond Smith

Anthony Ciro Vrba

James G Hansen

Kelly Justin McCrystle

Seung-Yub Lee

Zhu Li

Gregory Stock

Mark Wilson Ian Webster

Kevin Robert Hykes

Rossana Motta

Michael David Perry

Eric Robert Reuland

Victor Kelvin Sun

Kelly Justin Mccrystle

Jonathan Allen Coe

Gopal Sarngadharan

According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

Neuromodulation for metabolic conditions or syndromes

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves within a wall of (e.g., within adventitia surrounding a lumen of) an artery or other blood vessel, such as the common hepatic artery.

Modulation of targeted nerve fibers

The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.

Compounds, compositions and methods for making the same

Modulation of nerves innervating the liver

Neuromodulation methods to alter glucose levels

Methods of modulating nerves of the hepatic plexus

Therapeutic denervation of nerves surrounding a hepatic vessel

Balloon catheter neuromodulation systems

Glucose alteration methods

Hepatic neuromodulation using fluids or chemical agents

According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid deliver.

Gastroduodenal artery neuromodulation

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Boston, MA, United States of America

Scott Bradley Vafai