Amgen Inc.

Unl Holdings LLC

Syngenta Participations Ag

Stratasys, Inc.

Synthetic Genomics, Inc.

Verenium Corporation

Unitract Syringe Pty Ltd

Scott Beaver

Ian B Hanson

Kevin Lee Bokelman

Paul F Bente, Iv

Daniel Shawn Codd

Rajan Ramaswamy

John Christian Love

Sean M O'connor

Matthew J Clemente

Sheldon B Moberg

Scott Robert Gibson

Margaux Frances Boyaval

Lawton Laurence

Mark A Destefano

Basel Hasan Taha

Antonio Ubach

Danielle Feldman

William Michael Lafferty

Andrew James Carlson

Daniel Steven Kline

Daniel Davenport

Ryan Michael Agard

Gautam N Shetty

Nicholas J Ciccarelli

Alexander Libinson

Mark Majette

Anthony David Barghini

Adam Joseph Livingston

Robert Decker

Charles Wilson Tweedy

Ian P Dardani

Nathaniel Michael Peterson

Walter James Frandsen, Jr

Elizabeth Ann George

Kevin L Bokelman

Daniel S Codd

James Coleman Lee

Hwai Wen Chang

David Paul Weiner

Grace DeSantis

Laurence Warden

Connie Jo Hansen

Guy Menchik

Yoav Bressler

Evgeni Levin

Shaun Healey

Geoff Hazlewood

David Blum

Kevin Ready Campion

Alexander Varvak

Mark H Becker

Thomas Todaro

Kristine Chang

Robert Earl Simon

Thomas Woodward

Charles Hancock

Jonathan Bennhard Hedlund

Shane Scott Swamer

Paul F Iv Bente

Iv Bente Paul F

Scott R Gibson

John C Love

Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device may include a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector may define a sterile fluid flowpath between the container and the insertion mechanism. Optionally, a cannula initially disposed about the needle may be included. The cannula may be retained in the patient at an injection site created by the needle after the needle is withdrawn from the patient. Methods of assembly and operation are also provided.

Drug delivery device, method of manufacture, and method of use

The present invention provides devices and methods for establishing aseptic connections between two or more components or subassemblies. The devices may be used in medical devices such as drug delivery pumps (). In some embodiments, a connection is made between a drug container () and a fluid pathway connection assembly (). The fluid pathway connection assembly may include a connection hub (), a piercing member (), and a piercing member retainer (). The assembly may further include a first film () covering a cavity (A,A,A), thereby maintaining the aseptic condition of the cavity. The drug container may hold a fluid drug and include a pierceable seal (). A second film () may cover a recess () formed by the seal and thereby maintain the aseptic condition of the interior of the chamber. The piercing member may be caused to pierce the first and second film and the pierceable seal to open a fluid pathway for delivery of the fluid drug through the fluid pathway connection assembly.

Device and method for making aseptic connections

A user-initiated fluid pathway connection includes: a connection hub, a piercing member, a sterile sleeve, and a drug container having a cap, a pierceable seal, a barrel, and a plunger seal, wherein the piercing member is initially retained within the sterile sleeve between the connection hub and the pierceable seal of the drug container. The connection hub may include an internal aperture within the connection hub which functions as a flow restrictor and wherein a piercing member is connected to one end of the internal aperture and a fluid conduit is connected to another end of the internal aperture. A drug delivery pump with integrated sterility maintenance features includes a housing, upon which an activation mechanism, an insertion mechanism, a fluid pathway connection as described above, a power and control system, and a drive mechanism connected to a drug container are mounted. Methods of assembly and operation are also provided.

Sterile fluid pathway connection to drug containers for drug delivery pumps

A controlled delivery drive mechanism includes a drug container having a barrel and a plunger seal; a drive housing within which at least initially partially resides a piston having an interface surface and a drive rack; and a power spring. The piston is configured to contact and axially translate the plunger seal within barrel. The mechanism may be configured to convert rotational movement of a drive pinion to axial translation of the drive rack, or to convert axial force of a linear power spring into torsional motion of a drive pinion. A regulating mechanism meters the drive pinion such that the piston is axially translated at a controlled rate. The drug container may contain a drug fluid within a drug chamber for drug delivery at a controlled rate. The regulating mechanism may be an escapement regulating mechanism. A drug delivery pump includes such controlled delivery drive mechanisms.

Controlled delivery drive mechanisms for drug delivery pumps

Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device includes a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector defines a sterile fluid flowpath between the container and the insertion mechanism. A cannula initially disposed about the needle is included.

A method of providing nozzle calibration parameters for a 3D printer comprises: printing an arc pattern, printing an X-Y align pattern, and printing a head calibration pattern, measuring actual positions of drops, calculating deviations of said measured actual positions from expected positions, and calculating calibration parameters to correct for the deviations. Indicator drops may be used to allow built-in image recognition to find the calibration drops, and a cam system is provided to guide nozzle wipers.

Operation of printing nozzles in additive manufacture and apparatus for cleaning printing nozzles

Additive manufacturing or 3D printing produces considerable quantities of waste ink or resin during the course of additive manufacture. The waste ink is a hazardous substance and must be collected and disposed of accordingly. The present embodiments provide a waste ink collection device that collects the waste ink from the printing process, or from head cleaning and other incidental operations, stores the waste and cures it. The waste ink is thus rendered safe for conventional disposal. A waste ink disposal cartridge collects the waste ink and carries out curing.

Waste disposal for 3D printing

A system for three-dimensional printing is disclosed. The system comprises: a rotary tray configured to rotate about a vertical axis; a printing head, each having a plurality of separated nozzles; and a controller configured for controlling the inkjet printing head to dispense, during the rotation, droplets of building material in layers, such as to print a three-dimensional object on the tray.

Method and system for rotational 3D printing

The invention provides a lid mechanism suitable for use with automated instrumentation. The lid mechanism has a compact design enabling it to function in very small spaces, and therefore on very compact instrumentation. One embodiment of the lid mechanism has a nut positioned around a jackscrew; a motor translationally attached to the nut for driving rotational motion of the nut around the jackscrew and vertical motion of the jackscrew; a main shaft positioned around the jackscrew with a bearing support positioned on the main shaft; a moving support comprising a bearing guide track and positioned on the main shaft so that the bearing support is positioned within the bearing guide track; and a lid plate positioned on the moving support so that vertical movement of the moving support causes vertical movement of the lid plate and rotational movement of the moving support causes rotational movement of the lid plate. Also provided is an automated laboratory instrument having a lid mechanism of the invention.

Lid mechanism

Growing community of inventors

San Marcos, CA, United States of America

Scott Beaver