454 Life Sciences Corporation

Scott B Dewell

Jonathan Marc Rothberg

John W Simpson

Jan Berka

Joel S Bader

Keith McDade

Christopher M Colangelo

Michael Weiner

Jane Berka

Michael Philip Weiner

Disclosed herein are methods and apparatuses for sequencing a nucleic acid. These methods permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (&#x3e;10,000) of different oligonucleotides.

Apparatus and method for sequencing a nucleic acid

Method of sequencing a nucleic acid

Disclosed herein are methods and apparatuses for sequencing a nucleic acid. In one aspect, the method includes annealing a population of circular nucleic acid molecules to a plurality of anchor primers linked to a solid support, and amplifying those members of the population of circular nucleic acid molecules which anneal to the target nucleic acid, and then sequencing the amplified molecules by detecting the presence of a sequence byproduct such as pyrophosphate.

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New Haven, CT, United States of America

Scott B Dewell