Eli Lilly and Company

Other

Scott Alan Frank

Jeffrey A Dodge

David Andrew Coates

Timothy Alan Shepherd

Owen Brendan Wallace

Robert Dean Dally

Roger Ryan Rothhaar

Radhe Krishan Vaid

Aktham Aburub

Mark Steven Kerr

Ronald Jay Hinklin

David Michael Remick

John Arnold Werner

Xinchao Chen

Scott Alan Jones

Steven Wayne Pedersen

Douglas E Prather

Conrad Wilson Hummel

George Sal Lewis

Jeffrey A Ward

Kin Chlu Fong

Kin Chiu Fong

Jeffrey Alan Dodge

Geroge Sal Lewis

The embodiments of present invention provide processes for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms, such as tablets, made by these processes. Additionally, embodiments of the present invention provide tablets including 25 mg, 50 mg, 100 mg, or 200 mg free base equivalent of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate.

Processes and intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate, and preparation of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide acetate

The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms, such as tablets, made by these processes. Additionally, embodiments of the present invention provide tablets including 25 mg, 50 mg, 100 mg, or 200 mg free base equivalent of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate.

Processes and intermediate for the large-scale preparation of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate, and preparation of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide acetate

A reusable, pneumatic paint grenade that includes a dashpot timing mechanism for sudden release of compressed air that ruptures a frangible housing to disperse a dyed liquid or airsoft pellets after the paint grenade is thrown. The dashpot further comprises a plunger located in a cylindrical body. A lever in contact with the plunger of the dashpot forces the plunger downward to puncture a cartridge of compressed air with a sharp structure disposed between the plunger and the cartridge. The compressed air is prevented from escaping while the sharp structure remains in the cartridge. Once the lever is released, the plunger is forced into substantially its original position by a biasing mechanism and the force exerted by the air pressure within the cartridge. The cylindrical body can be filled with a viscous liquid to further slow movement of the plunger.

Reusable grenade

Abstract Compounds of a formula entitled, trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid, as a free acid or a pharmaceutically acceptable salt thereof, hydrate, and hydrate in crystalline form; pharmaceutical formulations; and methods of use are disclosed. 

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The present invention relates to a selective estrogen receptor modulator of formula I or Ia: (I) (Ia); or a pharmaceutical acid addition salt thereof; useful for treating vasomotor symptoms, in particular hot flashes, night sweats and other symptoms that affect women around menopause. 

Selective estrogen receptor modulators for the treatment of vasomotor symptoms

The present invention relates to a selective estrogen receptor modulator of formula I or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata. 

Selective estrogen receptor modulators containing a phenylsulfonyl group

This invention relates to a process for preparing certain 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates, intermediates, and congeners. Finally, the invention provides new 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates with formulations and methods for using the compounds.

Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and

Growing community of inventors

Indianapolis, IN, United States of America

Scott Alan Frank