New York University

Centocor, Inc.

Other

Phytera Incorporated

Scott A Siegel

David M Knight

Jan T Vilcek

John Ghrayeb

Junming Le

Peter E Daddona

Peter Dadonna

Christopher J Pazoles

John Ghraveb

Jumming Le

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-&#x3b1; (TNF&#x3b1;) and are useful in vivo diagnosis and therapy of a number of TNF&#x3b1;-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Methods of treating vascular inflammatory pathology using anti-TNF antibodies and fragments thereof

Methods of inhibiting TNF&#x3b1; activity in the blood of a patient

Methods of treating rheumatoid arthritis with anti-TNF antibodies

Methods of inhibiting or neutralizing TNF&#x3b1; in patients with tissue injury

Recombinant A2-specific TNF&#x3b1;-specific antibodies

Methods of treating psoriasis with anti-TNF antibodies

Anti-TNF antibodies and anti-TNF peptides, specific for tumor necrosis factor (TNF) are useful for in vivo diagnosis and therapy of a number of TNF-mediated pathologies and conditions, as well as polynucleotides coding for anti-TNF murine and chimeric antibodies, peptides, methods of making and using the antibody or peptides in immunoassays and immuno-therapeutic approaches are provided, where the anti-TNF peptide is selected from a soluble portion of TNF receptor, an anti-TNF antibody or structural analog thereof.

Anti-TNF antibody fragments

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-&#x3b1;(TNF&#x3b1;) and are useful in vivo diagnosis and therapy of a number of TNF&#x3b1;-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Methods of treating cachexia with chimeric anti-TNF antibodies

Methods of treatment of fistulas in Crohn's disease with anti-TNF antibodies

Methods of inhibiting TNF&#x3b1; in patients with neoplastic disease

Methods of treating disseminated intravascular coagulation by multiple administration of anti-TNF antibodies

The invention relates to anti-TNF antibodies, fragments, regions and derivatives thereof which are specific for human tumor necrosis factor-&#x3b1; (TNF&#x3b1;) and are useful in methods of treating psoriasis, as well as polynucleotides coding for murine and chimeric anti-TNF antibodies, and methods of producing anti-TNF antibodies, fragments, regions and derivatives thereof.

Methods of treating rheumatoid arthritis by multiple administration of anti-TNF antibodies

Growing community of inventors

Westborough, MA, United States of America

Scott A Siegel