Johns Hopkins University

Scott A Shuler

Zhiyong Xia

Jeffrey P Maranchi

Spencer A Langevin

Steven M Storck

Matthew W Logan

Reid E Messersmith

Jarod C Gagnon

Mairead E Bartlett

Korine A Ohiri

Michael J Presley

A bifunctional linker of Formula 1 wherein in Formula I, at least one of Rto Ris —COORand Ris —C-Calkyl(C-Calkynyl) or —C-Calkyl-C-Calkenyl(C-Calkynyl), preferably a terminal alkynyl. The bifunctional linker is used in a cycloaddition to tether two entities, for example a protein or antibody, and an active agent, to form a bisconjugate. The bifunctional linker also be used to form a conjugate, followed by cycloaddition in the presence of a comonomer composition to form a bisconjugate including a protein or antibody linked to an adhesive polymer network. Catalysis can be provided by a copper-containing paint on a surface to adhere the bisconjugate to the surface. Methods of synthesis and use of the bisconjugates imaging, diagnostic, and therapeutic applications are also described.

Bifunctional linker for bisconjugation, method of synthesis, and method of use

A method for printing a semiconductor material includes depositing a molten metal onto a substrate in an enclosed chamber to form a trace having a maximum height of 15 micrometers and/or a maximum width of 25 micrometers to 10 millimeters and/or a thin film having a maximum height of 15 micrometers. The method further includes reacting the molten metal with a gas phase species in the enclosed chamber to form the semiconductor material. The depositing the molten metal includes depositing a metal composition including the molten metal and an etchant or depositing the etchant separate from the molten metal in the enclosed chamber.

Method for printing wide bandgap semiconductor materials

A water harvesting device includes at least a first adsorption column including a first inlet, a first outlet, and a first interior region. A sorbent material is located within the first interior region of the first adsorption column. The sorbent material includes a metal organic framework (MOF) material including a plurality of metal ions or clusters of metal ions coordinated to one or more organic linkers, a plurality of nanofabrics comprising a hydrogel material, or a combination thereof.

Water harvesting device

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Baltimore, MD, United States of America

Scott A Shuler