Carl Zeiss Meditec Gmbh

Carl Zeiss Meditec Ag

Lehigh University

Carl Zeiss Ophthalmic Systems, Inc.

Carl Ziess Meditec, Inc.

Scott A Meyer

Matthew J Everett

Paul Francis Stetson

Yan Zhou

Martin Hacker

Keith E O'Hara

Claus Flachenecker

Rick A Williams

Xunchang Chen

Rudolf Murai Von Bünau

Xing Wei

Mary K Durbin

Harihar Narasimha-Iyer

Burkhard Wagner

Bagrat Amirbekian

Christoph Hauger

Ming Lai

Jay Wei

Rodney P Chin

Shahram Shawn Dastmalchi

Utkarsh Sharma

James Foley

Jochen Horn

Boon-Siew Ooi

Burkhart Wagner

Hery Susanto Djie

Keith E O'hara

Systems and methods to improve the visualization of vasculature in OCT angiography data are presented. In one embodiment, vessels having a particular orientation relative to one or more reference surfaces are highlighted. In another embodiment, the path of individual vessels can be analyzed to determine how many or what layers the vessels traverse. In another embodiment, regions which are typically not vascularized are analyzed for the presence of vessels. Techniques to minimize the impact of shadow artifacts are also presented and can be applied to any of the visualization approaches for further enhancement.

Enhanced vessel characterization in optical coherence tomograogphy angiography

Systems and methods for improving ophthalmic imaging by correlating the location of a measurement on the pupil of the eye with a quality of the measurement and further controlling subsequent measurements based on the quality are presented. Aspects of the invention include obtaining optical coherence tomography (OCT) measurements through cataracts or other media opacities, obtaining B-scans with minimized tilt, and automated OCT data acquisition of select structures in the eye. Embodiments of the invention directed towards imaging tissues with angle dependent layer contrast and mapping the size and location of cataracts in the eye are also described.

Systems and methods for improved ophthalmic imaging

A method for calculating the power of an intraocular lens including measuring an axial separation between the front surface of the cornea and the plane of the iris root; and determining the power of the intraocular lens using the measured axial separation together with other measured parameters and empirically determined lens constants.

Method for determining the power of an intraocular lens

For the pre-operative calculation of the power of an intraocular lens, three input parameters are needed: the axial length of the eye (AL), the refractive power of the cornea, and the distance between the front of the cornea and the back focal plane of the intraocular lens, the so-called effective lens position (ELP). The invention shows a novel approach to the determination of the ELP.

A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.

Method and apparatus for measuring motion of a subject using a series of partial images from an imaging system

Systems and methods for efficiently displaying large volumes of medical imaging data using pre-defined dynamic displays to illustrate key anatomic features are described. In a preferred embodiment, one or more pulse files comprising en face images of sub sections of the volume are displayed sequentially to the user in a playback loop. These displays can aid in navigation of data for review and future data acquisition. Additional images generated from the data can be displayed next to or overlaid on the pulse files.

Standardized display of optical coherence tomography imaging data

The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.

Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues

The present invention provides for the detection and display of polarization scrambling tissue without resolving the polarization state of the backscattered imaging beam. In one embodiment, we illuminate the tissue using two different polarizations. A first polarization determines a first image of high intensity while the second polarization determines a second image of low intensity. Comparison and combination of the first and second images determines tissue which scrambles the polarization in neighboring detection cells.

Imaging of polarization scrambling tissue

A solution for attaining high-precision and reproducible measurements during opthalmological biometry and imaging includes an illumination unit for producing a fixation marker, a device for transmitting the light of the produced fixation marker into the eye, a measurement device and a control unit. The illumination unit includes a device for the targeted change of the beam direction of the produced fixation marker. A camera for the detection of the line of vision of the eye is connected to the control unit. The control unit determines the sufficient congruity between detected line of vision and displayed beam direction of the produced fixation marker and, in dependence of the degree of probability of the congruity, triggers a measurement. The suggested arrangement is applicable for opthalmological diagnostic devices, which exhibit a camera and a measuring system, whereby measurements can be taken in all areas of the eye.

Arrangement for attaining high-precision measurements of an eye

Frequency domain optical coherence tomography (FD-OCT) systems and methods are provided. Thereby, a first measurement and a second measurement is performed, wherein in the first measurement an object region is illuminated by measuring light having a spectrum with a first spectral width and in the second measurement the object region is illuminated with measuring light having a spectrum with a second spectral width, wherein the first spectral width is at least 10% greater than the second spectral width. Further, during the first measurement intensities of spectral ranges of light having interacted with the object and being superimposed with reference light are detected, wherein a width of these spectral ranges is greater than a corresponding width during the second measurement. Thus, switching an axial field of view of structural information of the object across a depth direction is enabled upon minimizing radiation damage at the object.

Optical coherence tomography methods and systems

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Livermore, CA, United States of America

Scott A Meyer