Other

Scott A Gubler

Narayan K Athanikar

The present invention provides a process for preparing a chewing gum tablet, in which a chewing gum composition is cooled to a temperature at which the composition is brittle, and the composition is ground while brittle to form a fine powder. In a preferred process, the composition is cooled by mixing with a coolant, such as solid carbon dioxide, and the mixture is ground to a powder. The powder can be mixed with a pharmaceutical active ingredient capable of topical absorption in the buccal cavity or in the mucous layer of the upper or lower intestinal tract, and formed into a tablet. Preferably, the mixture of the powder, pharmaceutical active ingredient, and other additives such as coating agents, binders, additional active ingredients, and sweeteners, are granulated in a fluidized bed granulator prior to forming the mixture into a tablet. The resulting tablet provides a dosage form of the pharmaceutical active ingredient having a more accurate and uniform dose of the active ingredient.

Process for manufacturing a pharmaceutical chewing gum

A novel filter assembly (8) for fluid bed granulator, dryer or coater machines (1) which utilize a rigid filter frame (10) consisting of a solid bottom plate (4), a donut shaped top plate (3) with said top and bottom plates being connected by side rods (5) to form a cage like frame work. Said rigid filter frame (10) is reusable, around which a pleated (13) reusable flexible filter bag (9) is fitted and clamped (7), top support plate (2) and mounting plate (12) are connected by a threaded rod (6) with a sealing gasket (11) between them. Said filter assembly (8) is located inside said fluid bed machine's exhaust path so that when the process air is drawn through the filter bag (9) it forms around and through the filter frame (10) to cause a pleated (13) accordion effect in such a way that it allows the use of flexible filter media in a configuration that takes less space, gives better support to prevent tearing, is much easier to change and clean between product production run and can be continuously cleaned during operation by alternately providing reverse air flow through them.

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St. George, UT, United States of America

Scott A Gubler