Olatec Therapeutics LLC

Chemic Laboratories, Inc.

Chemsmart, LLC

Olatec Industries LLC

Jsb Pharma Development, LLC

Koda Therapeutics, LLC

Scott A Goodrich

Gerald S Jones

Joseph St Laurent

David M Bresse

George Maguire

Joseph P St Laurent

Described herein are compounds that act as antimicrobial agents, compositions comprising these compounds, and methods of their use in to treating infections caused by() or killing or inhibiting the growth of

Antimicrobial agents and compositions and uses thereof

Described herein are methods for making folic acid derivatives, intermediates, pharmaceutical compositions and uses thereof.

Compositions comprising folic acid derivatives, their preparations and methods of use

The present invention relates to purified compounds of 3-methanesulfonylpropionitrile, in which at least one of the hydrogen, oxygen, sulfur, and nitrogen atoms is substituted with a respective isotope that includes, but not limited toH (deuterium),H (tritium),C,C,N,O,O, andS. The purified compound has at least 90% purity. Preferred compounds are deuterated 3-methanesulfonylpropionitriles.

Deuterated 3-methanesulfonylpropionitrile

The present invention relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and 3-benzylsulfonylpropionitrile, or its pharmaceutically acceptable salts. The present invention also relates to methods of using the compound for treating inflammation or inflammatory-related disorders and pain.

Pharmaceutical use of 3-benzylsulfonylpropionitrile

The present invention is directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method comprises administering to the subject 3-benzylsulfonylpropionitrile, in an amount effective to reduce or eliminate the symptoms of the inflammatory skin disease or disorder. Topical administration and oral administration are preferred route of administration.

The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and 4-benzylsulfonyl-2-butenenitrile, or a pharmaceutically acceptable salt or solvate thereof. The present invention is directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 4-benzylsulfonyl-2-butenenitrile, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.

4-benzylsulfonyl-2-butenenitrile

The present invention relates to processes for preparing for preparing 3-(methylsulfonyl)propionitrile. The processes comprise the steps of first reacting 2-chloroethyl methyl sulfide with sodium cyanide or potassium cyanide in a solvent or a solvent mixture to form 3-(methylthio)propionitrile, and then reacting the isolated 3-(methylthio)propionitrile with acetic anhydride, acetic acid, and hydrogen peroxide to form 3-(methylsulfonyl)propionitrile.

Process for preparing 3-(methylsulfonyl)propionitrile

The present invention is directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method comprises administering to the subject 4-methylsulfonyl-2-butenenitrile, in an amount effective to reduce or eliminate the symptoms of the inflammatory skin disease or disorder. Topical administration and oral administration are preferred routes of administration.

4-methylsulfonyl-2-butenenitrile and its pharmaceutical use

The present invention is directed to a method of treating inflammation or pain. The present invention is also directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method comprises administering to the subject 3, 4-bis-benzylsulfonylbutyronitrile in an amount effective to reduce or eliminate the symptoms of the disease or disorder. Topical administration and oral administration are preferred route of administration.

Pharmaceutical use of 3, 4-bis-benzylsulfonylbutyronitrile

Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, methods of making compounds of formula (I) and their use in the treatment and/or prevention of diseases and disorders.

Fatty alcohol esters of hydroxycarboxylic acids

The present invention is directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method comprises administering to the subject 3, 4-bis-benzylsulfonylbutyronitrile in an amount effective to reduce or eliminate the symptoms of the inflammatory skin disease or disorder. Topical administration and oral administration are preferred route of administration.

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Stoughton, MA, United States of America

Scott A Goodrich