University of California

The J. David Gladstone Institutes

Scot J Stone

Robert V Farese, Jr

Sylvaine Cases

Ping Zhou

Chi-Liang Eric Yen

Nucleic acid compositions encoding mammalian DGAT2&#x3b1; polypeptide products with diglyceride acyltransferase activity, as well as the mammalian DGAT2&#x3b1; polypeptide products encoded thereby and methods for producing the same, are provided. The subject DGAT2&#x3b1; polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.

Diacylglycerol O-acyltransferase 2&#x3b1; (DGAT2&#x3b1;)

Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase and/or monoacylglycerol acyltransferase activity, as well as the polypeptide products encoded thereby, i.e., mammalian DGAT2&#x3b1; and MGAT1 polypeptide products, and methods for producing the same, are provided. Also provided are: methods and compositions for modulating DGAT2&#x3b1; and MGAT1 activity; DGAT2&#x3b1; and MGAT1 transgenic cells, animals and plants, as well as methods for their preparation; and methods for making diglyceride, diglyceride compositions, triglycerides and triglyceride compositions, as well as the compositions produced by these methods. The subject methods and compositions find use in a variety of different applications, including research, medicine, agriculture and industry applications.

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Fairfield, CA, United States of America

Scot J Stone