Life Technologies Corporation

Schuyler Corry

Kyle R Gee

Brian Agnew

Aleksey Rukavishnikov

Iain Johnson

Lawrence Greenfield

William Downey

Brian Filanoski

James Hirsch

The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention.

Oligosaccharide modification and labeling of proteins

The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a &#x3b2;-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a &#x3b2;-lactamase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a &#x3b2;-lactamase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a &#x3b2;-lactamase or instructions for using the components in an assay.

Optically-detectable enzyme substrates and their method of use

The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a &#x3b2;-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a &#x3b2;-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a &#x3b2;-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a &#x3b2;-lactmase or instructions for using the components in an assay.

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Eugene, OR, United States of America

Schuyler Corry