Leo Pharmaceutical Products, Ltd.

Leo Pharmaceutical Products Ltd. A/s

Leo Pharmaceutical Products Ltd. A/s (lovens Kemiske Fabrik

Leo Pharmaceutical Products Ltd. A/s (l.o Slashed.vens Kemiske Fabrik

Schneur Rachlin

Dorte Kirstein

Erik T Hansen

Ole Bent Nielsen

Ian Ahnfelt-Ronne

Edoardo Arrigoni-Martelli

Quinoline derivatives containing a diol as leukotriene antagonists

Isoserine derivatives and their use as leukotriene antagonists

Substituted quinolines and leucotriene antagonism treatment therewith

Substituted quinolines and medicinal use thereof

This invention relates to new compounds, salts, complexes and acylated derivatives thereof, methods of producing said compounds, intermediates used in the method, pharmaceutical compositions containing the present compounds and methods of producing same, and a method of treating patients using the present compounds, having the general formula (I) ##STR1## in which R.sub.1 represents hydrogen, alkyl, alkoxy, hydroxy, halogen, trifluoromethyl, or phenyl; R.sub.2 represents hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, or hydroxy; R.sub.3 represents alkyl, cycloalkyl which can be further mono- or disubstituted with methyl or ethyl, phenyl or phenyl-alkyl, optionally being further substituted; and R.sub.4 represents a 5- or 6-membered heterocyclic ring system containing at least one nitrogen atom and optionally further nitrogen, oxygen and/or sulphur atoms, said ring system optionally being further substituted; or said ring system optionally forming part of a larger fused ring system; and pharmaceutically acceptable, non-toxic salts, complexes and acylated derivatives thereof. The present compounds can be used in the therapy of rheumatoid arthritis, osteo-arthritis, and allied conditions in humans and domestic animals by enteral, parenteral or topical administration.

Quinolinyl guanidines having antiinflammatory, analgesic or antipyretic

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Vaerlose, Denmark

Schneur Rachlin