Nippon Kayaku Kabushiki Kaisha

Sayuri Kato

Hideo Sugimura

Akira Shiozawa

Kazuhisa Narita

Yuh-ichiro Ichikawa

Kenichi Matsubara

Yukihiro Nishiyama

Takemitsu Nagahata

Kouwa Yamashita

Yuka Sugawara

Hiroshi Akaba

This invention relates to cyclobutane derivatives represented by the following general formula (1) and physiologically acceptable salts thereof: ##STR1## wherein B represents a nucleic acid base derivative, R.sup.1 and R.sup.2 independently represent hydrogen atom, dialkylaminoacyl group, 1,4-dihydro-1-methylnicotinoyl group or substituted phosphoric acid group, provided that either one of R.sup.1 and R.sup.2 is a group other than hydrogen atom. The compounds of this invention exhibit a high oral absorbability and are metabolized in vivo into the compounds of formula (1a). Accordingly, the compounds of this invention are expectedly useful as antiviral agent.

Phenoxyphosphoryloxymethyl cyclobutyl purines

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Urawa, Japan

Sayuri Kato