Ionis Pharmaceuticals, Inc.

Sayten P Patel

Eric E Swayze

Punit P Seth

Thazha P Prakash

Michael T Migawa

Garth A Kinberger

Jinghua Yu

W Brad Wan

Guillermo Vasquez

Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.

Method for synthesis of reactive conjugate clusters

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Mundelein, IL, United States of America

Sayten P Patel