Chugai Seiyaku Kabushiki Kaisha

Other

The University of Tokyo

Sakai Toshiyuki

Sawako Ozawa

Fumio Watanabe

Naoki Harada

Hitoshi Iikura

Noriyuki Furuichi

Nobuo Shimma

Hidenori Takahashi

Masahiro Sakaitani

Masayuki Matsushita

Toshihiro Aoki

Pil-Su Ho

Yasushi Tomii

Kenji Takanashi

Ikumi Hyoudoh

Nobuhiro Oikawa

Eisaku Mizuguchi

Toshiyuki Tsukaguchi

Nobuya Ishii

Kenji Morikami

Isao Umeda

Toshiyuki Sakai

Jun Ohwada

Hirosato Ebiike

The present invention provides a compound represented by the formula (1):  

Heteroarylphenylurea derivative

The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G, G, Gand Gare each independently selected from &#x2014;N&#x2550; etc., Ring Gis selected from divalent aryl etc., A is selected from amino etc., Gis selected from oxygen etc., Gis selected from oxygen etc., Gis selected from &#x2014;CH&#x2014; etc., and Ris selected from Calkyl etc.

p27 protein inducer

It is intended to provide a compound represented by the formula (1): [wherein Ar is an arylene group to be attached selected from the following formula (2): (wherein * represents a binding site to a nitrogen atom and ** represents a binding site to T); T represents &#x2014;(O)&#x2014;R; R represents a C-Calkyl group or the like; n represents 0 or 1; X represents O or the like; R, Rand Rare independently selected from a hydrogen atom or C-Calkyl; or Rand Rmay join together with an urea structure containing the nitrogen atoms to which they bind to form a 5- or 6-membered heterocycle; Y represents CH or N], or a pharmaceutically acceptable salt thereof or a prodrug thereof and a pharmaceutical composition containing the same.

Pyrazolopyridine and pyrrolopyridine multikinase inhibitors

The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Yand Yare selected from &#x2014;N&#x2550; etc., Yand Yare selected from &#x2014;CH&#x2550; etc., A is selected from sulfamide etc., Ris selected from hydrogen etc., and Ris selected from Calkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.

Coumarin derivative having antitumor activity

An objective of the present invention is to provide water-soluble prodrugs that can be administered parenterally, and which show excellent water solubility and small interspecies or individual differences and are rapidly converted to the active form by chemical conversion. This invention provides water-soluble prodrugs represented by formula (1), or pharmaceutically acceptable salts, or hydrates or solvates thereof, (wherein,

Water-soluble prodrugs

Growing community of inventors

Kamakura, Japan

Sawako Ozawa