Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa

Retrophin, Inc.

Irbm-science Park S.p.a.

C.n.c.c.s. Scarl Collezione Nazionale Dei Composti Chimici E Centro Screening

Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.r.l.

Msd Italia S.r.l.

Savina Malancona

Steven Harper

Jesus Maria Ontoria Ontoria

Federica Ferrigno

Vincenzo Summa

Simona Ponzi

Jose Ignacio Martin Hernando

Giacomo Paonessa

Ilaria Biancofiore

Philip Jones

Daniel Elbaum

Michael Rowley

Rita Scarpelli

Frank Narjes

Ester Muraglia

Giovanna Pescatore

Emanuela Nizi

Olaf Kinzel

Barbara Attenni

Edith Monteagudo

Danila Branca

Sergio Altamura

Maria Cecilia Palumbi

Alberto Bresciani

Ralph Laufer

Alina Ciammaichella

Maria Veneziano

Maria Beconi

Maria Vittoria Orsale

Jose Ignacio Hernando

The present invention relates to a class of novel heterocyclic compounds, to pharmaceutical compositions containing the compounds and their use in the treatment of kinetoplastid infections.

Compounds for use in the treatment of kinetoplastid infection

Compounds having the following formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, D, E and Rare as defined herein, are provided. Methods comprising the use of such compounds for the treatment of neurological disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in the treatment of neurological disorders, also are provided. 

Cyclic phosphates and cyclic phosphoramidates for the treatment of neurologic disorders

The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as, at a lower concentration than the concentration required for the inhibition of the growth of mammalian cells.

Compounds for use in the treatment of parasitic diseases

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract. 

Saturated bicyclic heterocyclic derivatives as SMO antagonists

The present invention relates to thienopyrrole compounds of formula (I); wherein A, B, Y, Ar, n, Z and Xare as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections. 

Thienopyrroles as antiviral agents

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Pomezia, Italy

Savina Malancona