Genapsys, Inc.

Euveda Biosciences, Inc.

Saurabh Paliwal

Hesaam Esfandyarpour

Kosar Baghbani Parizi

Seth Stern

Meysam R Barmi

Paul M Kenney

Hamid Reza Rategh

Amirhossein Samakar

Zhizhong Yin

Raymond Cheong

Ali Nabi

Provided herein are systems and methods for processing and analyzing nucleic acids and other biomolecules. Methods may include processing nucleic acid molecules in an emulsion of droplets. Methods of analyzing nucleic acid molecules may include coupling nucleic acids to a bead or other support. Methods may include analysis of nucleic acid molecules using a redox mediator. In some cases, analysis of the nucleic acid molecule includes determining a nucleotide sequence of the nucleic acid molecule.

Systems and methods for nucleic acid sequencing

Provided herein are devices and methods suitable for sequencing, detecting, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other molecules. In some cases, the devices and methods provided herein are used for computation.

Systems and methods for biological analysis and computation

Microfluidic devices have been developed to perform a range of high-throughput biochemical and cell-based assays over recent years. A design for a microfluidic device has been developed that resembles a microtiter plate, by placing the test chambers (each test chamber contains cells) and top-loading drug inlets (at least one per test chamber) in a grid according to the ANSI/SBS standards, yet offers the miniaturization and fluid handling advantages of microfluidics. This ensures that the device design is compatible with fluid handling and imaging equipment already in use for drug screening. A range of topologies have been determined that allow placement of various elements of this microfluidic network within the grid alignment constraints. A resistance equalization methodology has also been developed to reduce variability across assays run in different chambers of the microfluidic device. Additionally, it offers orders of magnitude miniaturization over multiwell plates, and potentially more reliable fluid handling.

Microfluidic grid-based design for high throughput assays

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Mountain View, CA, United States of America

Saurabh Paliwal