Johns Hopkins University

Saurabh Navinchandra Patel

David Lee Guyton

David George Hunter

Robert L Fry

Julie Christine Sandruck

Apparatus and method are provided for assessing the direction of fixation of an eye by detecting polarization-related changes in light retroreflected from the fundus of the eye. Nerve fibers in the retina of the eye are birefringent and alter the polarization state of light traversing them as a function of their orientation. The nerve fibers are arrayed in a characteristic pattern in the retina, specifically radiating outward from the fovea and converging to the optic nerve head. By assessment of polarization-related changes in rctroreflected light from multiple retinal areas either sequentially or simultaneously, characteristic birefringence signatures of portions of the retina can be identified which are used to assess the direction of fixation of the eye. In addition, interference from the corneal birefringence is reduced by using incident light having a polarization state that is substantially independent of meridional direction. Circularly polarized light or non-polarized light is used for the assessment. Interference from the corneal birefringence is reduced still further by detecting polarization-related changes that are substantially independent of the meridional direction of the corneal birefringence. This is accomplished by detecting changes in ellipticity by measuring solely the Stokes parameter S.sub.3 or by measuring any two Stokes parameters. An alternative is measuring the overall intensity of the retroreflected light when the dichroism of the lutein pigment particles in the vicinity of the fovea is used for the assessment.

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Monmouth Junction, NJ, United States of America

Saurabh Navinchandra Patel