Sandoz Gmbh

Sandoz Pharm. Corp.

Saul S Kornblum

Samuel B Stoopak

Allen L Jacobs

Dennis R Feltz

Tablet formulations for the diffusable release of drugs in the gastrointestinal tract, which formulations protect the gastric mucosa from the effects of solid, gastric irritating drugs. The formulation comprises a drug tablet core, coated with a water permeable, gastrointestinal fluid insoluble polymeric coating, e.g., polymethyl methacrylate, polyethylene glycol polyvinylacetate, diethylphthalate and dioctyl sodium sulfosuccinate.

Gastrointestinal protective coating formulations

A stable ergot alkaloid soft gelatin capsule consisting essentially of a soft gelatin capsule shell and encapsulated therein a liquid center fill solution consisting essentially of a therapeutically effective amount of an ergot alkaloid of the formula ##STR1## wherein R.sub.1 is hydrogen or halogen,

Soft gelatin capsule with a liquid ergot alkaloid center fill solution

This invention provides controlled, e.g., sustained release of drugs from medicament formulations containing a plurality of medicaments, wherein a desirable release pattern is maintained for both low concentration and high concentration drugs of the formulation.

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Springfield, NJ, United States of America

Saul S Kornblum