City of Hope

Saul J Priceman

Stephen J Forman

Christine E Brown

John P Murad

Nanhai G Chen

Yuman Fong

Paul J Yazaki

Anna Kozlowska

Hee Jun Lee

Anthony K Park

Eric Lee

John (Jack) E Shively

David Colcher

Stephen J Foreman

Benham Badie

An oncolytic poxvirus encoding a truncated human CD19 is used in conjunction with a chimeric antigen receptor to treat solid tumors.

Oncolytic virus expressing a car T cell target and uses thereof

Chimeric antigen receptors targeted to TAG72 and the use thereof to treat ovarian cancer and other cancers are described.

TAG72 targeted chimeric antigen receptor modified T cells for treatment of TAG72-positive tumors

This disclosure relates to, inter alia, cells expressing both a chimeric antigen receptor (CAR) and membrane bound IL-12 and the use of these cells to target and treat cancers (e.g., solid tumors and cancers expressing CD19, CD22, BCMA, PSCA, HER2, TAG-72, and PSCA). The disclosure also relates to cells expressing a membrane bound IL-12.

Membrane-bound IL-12 for cellular immunotherapy

Chimeric transmembrane immunoreceptors (CAR) targeted to PSCA are described.

Chimeric antigen receptors targeted to PSCA

Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain targeted to HER2, a transmembrane region, a costimulatory domain and an intracellular signaling domain are described.

Chimeric antigen receptors targeting HER2

Growing community of inventors

Duarte, CA, United States of America

Saul J Priceman