Mesoscale Technologies, Llc.

Meso Scale Technology Llp

Satyanarayana Gudibande

Jacob N Wohlstadter

George B Sigal

Mark T Martin

James L Wilbur

A method and apparatus for performing electrochemiluminescence assays are presented. In exemplary embodiments of the present invention an apparatus comprises an ECL-inactive electrode surface having a first assay-ligand immobilized thereon and an ECL-active microparticle having a second assay ligand immobilized thereon. In exemplary embodiments of the present invention a method comprises (a) forming a mixture comprising an electrochemiluminescent label and a microparticle having a first assay-ligand immobilized thereon, (b) applying electrochemical energy to an electrode surface in the presence of said mixture, and (c) measuring emitted electrochemiluminescence, where the microparticle is ECL-active and where the electrode surface is ECL-inactive when electrochemical energy is applied to it in the presence of said mixture.

Methods and apparatus for improved luminescence assays using microparticles

Method and apparatus for improved luminescence assays using microparticles

Microparticles comprising a core and electrochemiluminescent moieties within the core and methods of using the same in assays.

The present invention relates to methods, reagents and compositions, for conducting electrochemiluminescence binding assays which improve one or more characteristics of the assay or the instruments used to conduct the assay. The method is achieved using microparticles that include electrically conductive material. The electrically conductive material has one or more copies of an assay ligand immobilized an its outer surface and a plurality of electrochemiluminescent moieties immobilized an its outer surface. The assay ligand may be linked to the electrochemiluminescent moiety.

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Gaithersburg, MD, United States of America

Satyanarayana Gudibande