Ranbaxy Laboratories, Inc.

Satyananda Misra

Yatendra Kumar

Rajesh Kumar Thaper

Jag Mohan Khanna

S M Kumar

Mohan Prasad

Praveen Kumar Neela

The present invention relates to a cost effective and industrially advantageous process for the preparation of tolterodine and pharmaceutically acceptable salts thereof.

Process for the preparation of tolterodine

A process for preparing simvastatin from lovastatin or mevinolinic acid in salt form comprises treating either starting material with cyclopropyl or butyl amine, the pyranone ring thereby being opened when lovastatin is the starting material, adding a methyl group to the 2-methylbutyrate side chain, and thereafter closing the open pyranone ring to produce simvastatin. The process is performed without protecting and deprotecting the two hydroxy groups of the open pyranone ring. In a preferred embodiment, the starting material is treated with cyclopropyl amine which produces simvastatin via the novel intermediate lovastatin cyclopropyl amide.

Key intermediates in the manufacture of simvastatin

Process for manufacturing simvastatin from lovastatin or mevinolinic acid

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New Delhi, India

Satyananda Misra