Sanford Burnham Prebys Medical Discovery Institute

University of Central Florida Research Foundation Inc

University of Pennsylvania

Duke University

Sanford-Burnham Medical Research Institute

Satyamaheshwar Peddibhotla

Paul M Hershberger

Patrick R Maloney

Anthony B Pinkerton

Michael P Hedrick

Otto Phanstiel

Hampton Sessions

Holly Moots

Marc G Caron

Lawrence S Barak

Daniel Kelly

Teresa Leone

Byungyong Ahn

Richard Vega

Lawrence Barak

Various embodiments relate to compounds and methods useful for preventing or treating a cancer in a subject. The method may include administering to a subject a composition according to any of the embodiments described herein in an amount effective to inhibit metastatic activity or tumor growth in the subject.

Non-polyamine based polyamine transport inhibitors and their use in the treatment of human cancers

Formulations and methods for reducing blood glucose and/or increasing insulin signaling in a subject have been developed. The formulations include SBI-477 and compounds based on SBI-477 i.e., SBI-477 analogs (collectively, SBI-477 compounds) and/or Mondo family inhibitors, in an effective amount to inhibit intracellular lipid accumulation and/or increase cellular glucose uptake when compared to levels in a control subject not administered the composition. Also disclosed are methods of reducing intracellular lipid accumulation and/or increase glucose uptake in a subject in need thereof. The method includes administering to the subject an effective amount of SBI-477 compounds and/or Mondo family inhibitor to reducing intracellular lipid accumulation and/or increase glucose uptake in the subject. Also disclosed are method for treating one or more Myc-driven cancers, including neuroblastoma, lung squamous cell carcinoma/lung adenocarcinoma, liver hepatocellular carcinoma, colon adenocarcinoma, acute myeloid leukemia, and breast invasive carcinoma.

Modulators of myocyte lipid accumulation and insulin resistance and methods of use thereof

Anthranilic acid derivatives and their use in the treatment of human cancers

Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Small molecule agonists of neurotensin receptor 1

Growing community of inventors

La Jolla, CA, United States of America

Satyamaheshwar Peddibhotla