Mitsubishi Tanabe Pharma Corporation

Satoshi Yuki

Takuma Nakano

Hiroko Suzuki

Masahiko Tanaka

Motonori Hashimoto

Katsumi Kurita

Tadashi Tanaka

Jyunichi Eguchi

Naomi Asahara

Narihiko Yoshii

Naruhiko Yoshii

A drug for the treatment of cerebrovascular disorders associated with insufficient cerebral circulation such as ischemic stroke, which comprises a pharmaceutically effective amount of a pyrazolone compound of structural Formula (I): or a pharmaceutically acceptable salt thereof, or a pseudo-polymorphic form thereof, administered at a controlled dose so that the plasma concentration of unchanged form is kept constant for a predetermined period of time and so that the compound may exhibit a higher effect.

Pyrazolone compounds useful for treatment of cerebrovascular disorders associated with ischemic stroke

The present invention provides a pharmaceutical formulation comprising paraoxonase (PON), a purification and stabilization method of PON, and an agent for prophylactic and/or therapeutic treatment of a disease resulting from ischemia reperfusion and/or cerebral infarction containing PON as an active ingredient.

Pharmaceutical formulations comprising paraoxonase

It is intended to provide drugs for treating ischemic diseases which are safe and have little side effects. Namely, drugs having a combination of an antithrombotic agent and a pyrazolone derivative defined in the description or its pharmaceutically acceptable salt.

Drugs comprising combination of antithrombotic agent with pyrazolone derivative

A therapeutic and/or prophylactic agent for nervous system disorder comprising as the active ingredient substances having an effect of improving calcium ion uptake of cardiac sarcoplasmic reticulum and/or an effect of inhibiting overaccumulation of intracellular calcium ions is offered. Preferably, the therapeutic and/or prophylactic agent for disease selected from the group consisting of cerebrovascular disease, traumatic head injury and postencephalitis and the therapeutic and/or prophylactic agent for disease selected from the group consisting of dementia and neuronal degeneration disease are offered.

Remedies and/or preventives for nervous system disorders

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Tokyo, Japan

Satoshi Yuki