Ube Industries, Inc.

Satoshi Umezaki

Yusuke Shiraishi

Tomio Kimura

Noriaki Iwase

Shigeyuki Kono

Masahiro Kojima

Shigeru Ushiyama

Hidetoshi Sunamoto

Yasuhiro Aga

Sayaka Ogi

Takashi Matsushita

Kazuhiro Onuma

Makoto Okudo

Masaaki Matoyama

Hayato Nishiyama

Ken-ichi Komori

Koji Ito

Yasunori Tokunaga

Kenji Yoneda

Haruka Yamada

Tomoko Kanda

Naoya Kinoshita

The present invention provides a compound that is highly safe and useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compound, a method for producing the compound, and the like. Specifically, the present invention provides a compound represented by the following general formula (I): [wherein: Aand Aeach independently represent an inhibitor residue having at least one activity selected from an enteropeptidase inhibitory activity and a trypsin inhibitory activity; and Z represents a spacer that links Ato A] or a pharmaceutically acceptable salt thereof.

Double-headed protease inhibitor

Methods of producing a compound represented by formula (I) or a pharmacologically acceptable salt thereof include: wherein Lis an optionally substituted Calkylene group or the like, Lis a single bond or the like, Lis a single bond or the like, R, R, and Rare each independently an optionally substituted Calkyl group or the like, Ris a hydrogen atom or the like, and Ris a hydrogen atom or the like.

Substituted dihydropyrrolopyrazole compound

The present invention provides a compound represented by the general formula (Ia) or a pharmacologically acceptable salt thereof. In the general formula (Ia), two R moieties each independently represent a Calkyl group or the like; and R, Rand Reach independently represent an optionally substituted linear or branched Calkyl group. 

Substituted dihydropyrrolopyrazole derivative

Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof: wherein Lis an optionally substituted Calkylene group or the like, Lis a single bond or the like, Lis a single bond or the like, R, R, and Rare each independently an optionally substituted Calkyl group or the like, Ris a hydrogen atom or the like, and Ris a hydrogen atom or the like.

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Ube, Japan

Satoshi Umezaki