Msd K.k.

Banyu Pharmaceutical Co. Ltd

Satoshi Sunami

Keiji Takahashi

Makoto Bamba

Fuyuki Yamamoto

Toshihiro Sakamoto

Kenji Niiyama

Hidetomo Furuyama

Takashi Yoshizumi

Yasuhiro Goto

Takeshi Sagara

Hiroshi Hirai

Sachie Otsuki

Toshihide Nishibata

Yoshikazu Iwasawa

Morihiro Mitsuya

Tetsuya Sugimoto

Yoshiyuki Sato

Hideya Komatani

Mikako Kawamura

Kaori Kamijo

Takashi Hashihayata

The invention relates to compounds of a general formula (I): wherein Aris an optionally-substituted aryl or heteroaromatic group; Ris an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; Ris a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; Ris a hydrogen atom or a lower alkyl group; Ris a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of &#x2014;N(R)R; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

Dihydropyrazolopyrimidinone derivatives

The invention relates to compounds represented by the general formula (I) and the like. In the formula, Ardenotes an aryl or heteroaryl group which may have a substituent; Rdenotes a hydrogen atom, or denotes a C1-C6 alkyl, aryl, aralkyl or heteroaryl group which may have a substituent; Rdenotes an aralkyl group or a group represented by the formula (a); and Rdenotes a hydrogen atom or a C1-C6 alkyl group. The compounds of the invention have an excellent Wee1 kinase inhibitory effect, and therefore are useful in the field of medicine, especially in the field of treatment of various cancers. 

The present invention relates to a compound of General Formula (I) below, among others. In the Formula, Aris an optionally substituted aryl or heteroaryl group; Ris a hydrogen atom, an optionally substituted C1-C6 alkyl group, or an optionally substituted aryl, aralkyl, or heteroaryl group; Ris an optionally substituted aryl, aralkyl, or heteroaryl group; and Ris a hydrogen atom or a C1-C6 alkyl group. A compound of the present invention has an excellent Wee1 kinase inhibiting effect, and is therefore useful in the filed of medicine, particularly in various types of cancer therapy. 

Dihydropyrazolopyrimidinone derivative

The invention relates to a compound of a general formula (I): wherein Aand Aeach mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; Rmeans a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; Rmeans an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of &#x2550;NH or &#x2550;O, etc. Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.

Bicycloaniline derivative

The invention is to provide a novel anticancer agent or sensitizer for cancer chemotherapy or radiotherapy. A compound of a general formula (I): wherein A means an aryl group or a heteroaryl group, or a group of a formula (a): Rmeans a &#x2014;(C&#x2550;O)O(C1-C6)alkyl group, a &#x2014;(C&#x2550;O)O(C2-C6)alkenyl group, a &#x2014;(C&#x2550;O)O(C3-C6)cycloalkyl group, an aryl group or a heteroaryl group; Rand Reach mean a hydrogen atom, a halogen atom, a hydroxyl group, a carboxyl group, a &#x2014;(C&#x2550;O)O(C1-C6)alkyl group or a group of &#x2014;(C&#x2550;O)N(R)R; Rmeans a hydrogen atom or a (C1-C6)alkyl group, and the like have an excellent Wee1-kinase-inhibitory effect, and are therefore useful in the field of medicine, especially in the field of various cancer treatments. 

Pyrimidopyrimidoindazole derivative

Substituted pyrazolo[3,4-d]pyrimidinone derivatives

The present invention relates to a compound represented by Formula [I] or a pharmaceutically acceptable salt or ester thereof: wherein:

Substituted imidazole derivative

Growing community of inventors

Toride, Japan

Satoshi Sunami