Otsuka Pharmaceutical Company, Limited

Kikuchi Co., Ltd.

Otsuka Chemical Co., Ltd.

Japan Agency for Marine-earth Science and Technology

Nippon Marine Enterprises, Ltd.

Satoshi Shimizu

Shin Miyamura

Haruka Takahashi

Hiroshi Yamashita

Nobuaki Ito

Tatsuyoshi Tanaka

Hideaki Kuroda

Kunio Oshima

Jun Matsubara

Kazumi Kondo

Takeshi Kuroda

Tae Fukushima

Hisao Hoshino

Shingo Shikuwa

Geraldine C Harriman

Masaki Suzuki

Akira Takahashi

Muneaki Kurimura

Amy M Elder

Shinichi Taira

Kevin J Hodgetts

Jason S Newcom

Takao Minagawa

Indranath Ghosh

Shigeki Kishihara

Tatsushi Yurudume

Krishna Reddy Valluru

Abhishek Dogra

Yusuke Kato

Takashi Hayashi

Yoshitaka Watanabe

Yasuo Oshiro

Yohji Sakurai

Takahiro Tomoyasu

Takao Taki

Kazuaki Kakehi

Yasuo Koga

Motohiro Itotani

Hiroaki Asai

Fumitaka Goto

Kiyoshi Hatakeyama

Norihiko Kikuchi

Yoko Sakamoto

Naohiro Hayashi

Minoru Kashimoto

Junji Takaba

Kouji Haya

Satoru Nakazato

Masaru Nishida

Yahiro Shimizu

Sou Suzuki

Atsushi Azuma

Makoto Noudou

Hiroyuki Osaka

Wakako Hirano

Kazunari Izumi

Yosiyuki Morisita

Takuya Maekawa

Amy Elder

The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.

Piperazine-substituted benzothiophenes for treatment of mental disorders

Methods of treating disorders using compounds that modulate striatal-enriched tyrosine phosphatase (STEP), such as those of formula (III), and composition thereof are described herein. Exemplary disorders include schizophrenia and cognitive deficit. 

Therapeutic compounds and related methods of use

The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety. 

Compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat a disorder, e.g., schizophrenia and cognitive deficit, in a subject are described herein. The compounds disclosed herein include quinoline and quinazoline-containing compounds that modulate striatal-enriched tyrosine phosphatase (STEP) activity.

A low-molecular-weight polysulfated hyaluronic acid derivative useful for treatment of an allergic disease. An agent for treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB); wherein n represents a number of 0 to 15; R's each independently represent a hydrogen atom or an SOH group etc.

Low-molecular polysulfated hyaluronic acid derivative and medicine containing same

A heterocyclic compound or a salt thereof represented by the formula (1): where Rrepresents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and Rrepresents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety. 

Derivatives of 4-piperazin-1-yl-4-benzo[B]thiophene suitable for the treatment of CNS disorders

A reduction of the unevenness of a temperature increase at the end of heating work can be achieved without specific equipment, and with securing the shortening of the working time, which is an advantage of a bulk heating. When a region to be heated of an article made of a thin sheet is heated inductively so that the whole region thereof reaches a temperature equal to or more than a target temperature using an inductive portion of a heating inductor, to which a high-frequency current is applied by a power supply device, by stopping or reducing temporarily the power application of the high-frequency current to the heating inductor during the temperature increase, a temperature difference in the region to be heated is reduced so that the unevenness of the temperature increase at the end of the heating work is reduced by the step of reducing the temperature difference.

Method and device for thin plate article induction heating, and thin plate article

A heat treatment operation can be executed, suppressing a wave-shaped deformation at a non heat-treatment region of an article to be heat treated. To an elongated-shaped article to be heat treated to which a raised portion extending in the longitudinal direction is formed, a hardening region, as a heat-treated region defined to extend in a longitudinal direction at a part of the raised portion, and a non-hardening region, as a non-heat-treated region defined to extend in the longitudinal direction at flange portion, and other parts of the raised portion are arranged side by side in a width direction orthogonal to the longitudinal direction. The flange portion is clamped by a first and a second clamp, arranged in the longitudinal direction, and one first clamp is a tight clamp for holding fixedly the flange portion and a plurality of second clamps are loose clamps for clamping loosely the flange portion, allowing the article to be heat treated to be convex on the side of the heated hardening region.

Clamp device and clamp method for heat-treated article

A press formed article such as a center pillar or the like for a vehicle having a demanded strength distribution achieved by hardening through induction hardening or the like, and a method and an apparatus for performing induction hardening on the press formed article. The center pillar () being a press formed article has an intermediate top portion () which extends in a longitudinal direction of the center pillar (), and two blade portions () which are both bent in the same direction from both sides of the intermediate top portion (), in which hardening regions (Q) are provided on both sides of the intermediate top portion (), extending over the intermediate top portion () and the blade portions (). These hardening regions (Q) hardened by the induction hardening apparatus are regions in a form which widens toward the end and continuously expand from the upper portion to the lower portion of the center pillar (). Therefore, the ratio between the hardening regions and non-hardening regions changes in the longitudinal direction of the center pillar (), resulting in a demanded strength distribution.

Press molding and its high frequency quenching method and its high frequency quenching system

Growing community of inventors

Tokushima, Japan

Satoshi Shimizu