Astellas Pharma Gmbh

Takeda Pharmaceutical Company Limited

Satoshi Sasamura

Susumu Yamaki

Jiro Fujiyasu

Tomoyoshi Imaizumi

Tomohki Satou

Kazuki Okada

Kazuhiko Ohne

Takeshi Hondo

Yasuharu Urano

Toru Asano

Keisuke Matsuura

Shigehiro Takase

Hideyuki Muramatsu

Osamu Kaneko

Yuka Koike

Motoo Kobayashi

Yasuhisa Tsurumi

[Problem] To provide a compound which is useful as an agent for preventing and/or treating kidney diseases. [Means for Solution] The present inventors have studied compounds having a trypsin inhibitory activity, and have confirmed that a guanidinobenzoic acid ester compound has a trypsin inhibitory activity, thereby completing the present invention. The guanidinobenzoic acid ester compound of the present invention can be used as an agent for preventing and/or treating kidney diseases (for example, chronic kidney disease, acute glomerulonephritis, acute kidney injury, and the like) as an agent which will substitute low-protein diet therapy, and/or as an agent for preventing and/or treating trypsin-related diseases (for example, chronic pancreatitis, gastroesophageal reflux disease, hepatic encephalopathy, influenza, and the like).

Guanidinobenzoic acid ester compound

[Problem] Provided is a compound which is useful as an agent for preventing and/or treating renal diseases. [Means for Solution] The present inventors have conducted extensive studies on compounds having a trypsin inhibitory action, and as a result, they have found that a guanidinobenzoic acid compound has a trypsin inhibitory action, thereby completing the present invention. The guanidinobenzoic acid compound of the present invention can be used as an agent for preventing and/or treating renal disease as an agent which will substitute low-protein diet therapy, and an agent for preventing and/or treating trypsin-related diseases, for example, pancreatitis, gastroesophageal reflux disease, hepatic encephalopathy, influenza, and the like.

Guanidinobenzoic acid compound

A cyclic peptide compound of the following general formula (I): Wherein R, Rand Rare defined in the description, or a salt thereof. The compound (I) is useful for the prophylactic and/or therapeutic treatment of hepatitis C. 

Cyclic peptide compound

Growing community of inventors

Tokyo, Japan

Satoshi Sasamura