Tokyo Electron Limited

Chugai Seiyaku Kabushiki Kaisha

Hoffmann-la Roche Inc.

Daiwa Seiko, Inc.

Takenaka Komuten Co., Ltd.

Tomokiyo White Ant Co. Ltd.

Satoshi Saitoh

Atsushi Nakamura

Masakazu Fukuda

Nobuyuki Tanaka

Yosuke Watanabe

Atsushi Matsuo

Harunobu Kusumoto

Hirotaka Imai

Maki Kuwayama

Akihiro Terada

Hisashi Hosomi

Tsutomu Tanaka

Tsugio Adachi

Chifumi Seida

Kensaku Hosoguchi

Kishore Ravuri

Kohei Soeda

Shigetaka Tomokiyo

Nuria Sancho Oltra

Teruo Kaneda

Jeremy Duboeuf

Robert Kopf

Hiroshi Mifune

Wei Chen

Masaya Takahashi

Toshiharu Furudate

Mituoki Yamamoto

Provided is a pharmaceutical formulation with reduced particle formation, comprising an anti-coagulation factor IXa/X antibody (bispecific monoclonal antibody) that substitutes for coagulation factor VIII, or an anti-IL-6 receptor antibody that inhibits binding to the interleukin 6 receptor. Provided is a pharmaceutical formulation comprising an aqueous solution comprising a polyoxyethylene polyoxypropylene glycol (poloxamer),

Pharmaceutical formulation comprising aqueous solution of antibody

As antibody variants and isoforms having reduced FVIII mimetic activity than Emicizumab, the antibody variants having some specific amino acid residues in the variable region cleaved out and missing (Q-CDR-Clipped Variants) and the antibody isoforms having inter-heavy chain disulfide bonds less susceptible to reduction under mild reducing conditions (Protected Disulfide Isoforms) are provided.

Antibody variant and isoform with lowered biological activity

A golf club shaft is constructed by a pipe-shaped body in which a sheet of reinforced fiber prepreg impregnated with synthetic resin is rolled. The golf club shaft includes: a front end portion to which a club head is attached; and a grip portion arranged on the opposite side to the front end portion, wherein a portion, the flexural rigidity of which is the maximum, is arranged on the front end portion side of the grip portion of the pipe-shaped body. The golf club shaft has a characteristic by which user's requirement can be satisfied.

Golf club shaft

A probe apparatus for inspecting electrical characteristics of a microelectronic element formed on a substrate and having a plurality of pads including a probe card having a plurality of probe needles, an image pick-up device for picking up images of the pads and the probe needles, a registration device which previously stores pad position information indicating pad positions of at least specified of the pads and needle position information indicating needle positions of at least specified of the plurality of probe needles, the needle positions being obtained by an actual measurement based on the images picked up by the image pick-up device, and a control processor for executing a task for detecting imaginary needle marks formed on the pads by imaginarily bringing the specified probe needles and the pads corresponding thereto into contact with each other, by overlapping the first position information and the pad position information of the microelectronic element, a task for detecting positional deviation information indicating a positional deviation between the needle marks and the pads, and a task for correcting a positional deviation between the pads and the probe needles in accordance with the positional deviation information.

Probe apparatus for inspecting electrical characteristics of a

A robot system for exterminating termites living in wood structural members under the floor of an architectural structure. The robot system comprises a robot including an onboard computer which is electrically connected through radio communication with a host computer located outside the robot. The robot includes a main body and is equipped with a locomotive mechanism including a pair of caterpillars located on the opposite sides of the main body. The caterpillars are driven by driving motors mounted on the robot and can be independently operated. The robot includes a mechanism for controlling the vertical positions of various sections of the main body relative to the caterpillars. A nozzle mechanism for spraying chemical or insecticide and a CCD camera are mounted on the main body. The onboard computer and host computer are operatively associated with each other to control the driving motors, the vertical position controlling mechanism, the nozzle mechanism and the CCD camera.

Intellectual working robot of self controlling and running

The present invention relates to a gravity type oceanic structure and its stable installation wherein a skirt is provided downward on the outside periphery of the lower end of the part to be settled and fixed on the sea bed. When the structure is settled on the sea bed, the skirt is pushed into the sea bed foundation to intercept penetration of sea water from the circumference into the structure, and sea water in the skirt is adequately discharged by draining means to make the internal pressure equal to the atmospheric pressure. Buoyancy is thereby eliminated so that the bottom surface of the structure is fixed firmly to the sea bed.

Gravity type oceanic structure and its stable installation

Growing community of inventors

Tokyo, Japan

Satoshi Saitoh