Shionogi Company Limited

Satoshi Orita

Gaku Sakaguchi

Akihiko Saiga

Kouichi Okumura

Hisanaga Igarashi

Kazuhiko Maekawa

Hikaru Sonoda

Rie Hayashi

A novel chordin-like polypeptide is found out in a protein secreted from mesenchymal stem cells. This polypeptide is useful as a cancer marker and a remedy for parotid cancer, lung cancer, esophagus cancer, gastric cancer, duodenal carcinoma, kidney cancer, ureteral cancer, testicular cancer, ovarian cancer, uterine cancer, leukemia, intestinal cancer, colon cancer, rectal cancer, biliary cancer or thyroid cancer cells, etc. Moreover, it is found out that the above polypeptide has an activity of modulating bone differentiation. Thus, this polypeptide is also useful as a bone disease marker and a remedy for bone diseases such as arthritis deformans, rheumatoid arthritis and osteoporosis.

Polypeptide and DNA thereof

A DNA molecule having a gene expression repressing function derived from human T-cell leukemia virus type I (HTLV-I) existing in a region which is missing in a mutant provirus that is expressing p21Xm RNA but exists in the genome of a complete provirus, and a plasmid including the DNA molecule are provided. Furthermore, a novel protein (TRP-1) which specifically binds to U5RE and a structural gene for the protein is provided, which can be useful for elucidation of the transcription repression activity and elucidation of the oncogenesis mechanism of neurocytes, in which a transcriptional repressive region (U5RE) existing in the U5 region of human T-cell leukemia virus type I gene LTR is involved. Furthermore, an expression vector including the gene, a transformant into which the expression vector is introduced, and a process for producing the TRP-1 protein using the transformant are provided.

DNA molecule relating to suppression of gene expression and novel protein

Growing community of inventors

Osaka, Japan

Satoshi Orita