Other

Meiji Seika Pharma Co., Ltd.

The Kitasato Institute

School Juridical Person Kitasato Institute

Meiji Seika Kaisha, Ltd.

The Kitasato Institute (a School Juridical Person)

Aphoenix, Inc.

Satoshi Omura

Achim Harder

Hiroshi Tomoda

Ryo Horikoshi

Toshiaki Sunazuka

Mariko Tsuchida

Gerd Kleefeld

Olaf Hansen

Haruo Ikeda

Kazuhiko Oyama

Kimihiko Goto

Tohru Nagamitsu

Georg Von Samson-Himmelstjerna

Masaki Ohtawa

Kenichiro Nagai

Akira Nakagawa

Haruko Yamabe

Carolin Ludwig

Daisuke Matsuda

Yumiko Ogasawara

Taichi Ohshiro

Ruiko Oiwa

Kazuo Tsuzuki

Robrecht Froyman

Hideaki Shima

Sugawara Akihiro

Hirose Tomoyasu

Shiomi Kazuro

Andreas Turnberg

This invention provides a novel non-natural pharmaceutical compound having a different mechanism than statin drugs and having a selective inhibitory activity against ACAT2. This invention relates to the compound represented by Formula (I), a salt thereof, or a solvate thereof: 

Pharmaceutical compound having inhibitory activity against cholesterol acyltransferase isozyme 2 (ACAT2)

A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein Ris an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula &#x2014;O&#x2014;CH(R)&#x2014;Rwhere Ris a lower alkoxy group and Ris an aryl group, and Ris carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a &#x2014;CH-acyloxy group and Ris an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of Rand Ris a group other than acetoxy, or Rand Rtaken together form a group of the formula &#x2014;O&#x2014;CH(R)&#x2014;O&#x2014; where Ris an aryl group.

Pyripyropene derivative having ACAT2 inhibiting activity and stable to metabolizing enzymes

Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier: 

Pest control agents

Disclosed is a compound usable as a pest control agent and has excellent pest control activity. A compound represented by formula (I) has excellent pest control activity. The compound or an agriculturally or horticulturally acceptable salt thereof is thus useful as a pest control agent. 

Pest control agent

There is provided a pest control agent comprising a compound represented by formula (I) as active ingredient. 

Macrolides PTL-448 A and B, which can be prepared by aerobic cultivation of Streptomyces ambofaciens ATCC 15154 in the presence of a macrolide intermediate selected from protylonlide, 5-O-mycaminosylprotylonolide, 20-hydroxy-5-O-mycaminosylprotylonolide and 20-oxo-5-O-mycaminosylprotylonodide, and macrolides PTL-448 C and D, which can be prepared by acidic hydrolysis of PTL-448 A and B are useful antibiotics.

Macrolide antibiotics, pharmaceutical compositions and methods of use

11-Thioether and certain C-20 acetal and thioacetal derivatives of tylosin and demycarosyltylosin are effective antibacterial agents. Processes for preparing, formulations containing, and methods of treating bacterial infections with these derivatives are provided.

Thioether derivatives of tylosin

20-Amino derivatives of tylosin and desmycosin are active against bacteria and Mycoplasma.

20-Amino tylosin derivatives and pharmaceutical compositions containing

Trichostatin (I) is disclosed to be useful as an antiprotozoal agent for the treatment of diseases in man and animals. Also disclosed are pharmaceutical compositions comprising trichostatin for treating protozoal infections. Trichostatin has the structure: ##STR1##

Trichostatin as an antiprotozoal agent

Growing community of inventors

Tokyo-to, Japan

Satoshi Omura