Nissan Chemical Industries Limited

Asahi Kogaku Kogyo Kabushiki Kaisha

Kabushiki Kaisha Kobe Seiko Sho

Satoshi Nakano

Takayuki Sensui

Isamu Hirai

Osamu Sato

Masato Yamamoto

Akio Takahashi

Toshimasa Yamanaka

Toshiyuki Kitazawa

Shunsuke Iwamoto

Yukihiro Shigeta

Norihisa Ishiwata

Hirofumi Ota

Takenao Shishikura

Katsuaki Miyaji

Kazufumi Yanagihara

Yutaka Hirokawa

Shingo Owada

Masato Horikawa

Nobuhiko Matsudo

Masao Yamamoto

Koji Toyama

Kazuya Takeuchi

Mariko Ishida

Shunuske Iwamoto

Katsuaki Myaji

Daisuke Saito

Junko Takada

Shigehiro Yamane

The object of the present invention is to provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) by a reaction of the corresponding amino compound having a carboxyl group(s), thiocarbonyldiimidazole and a base, in one step with high purity. An amino compound having a carboxyl group(s) is reacted with thiocarbonyldiimidazole in a solvent in the presence of a base to obtain an isothiocyanate compound having a carboxyl group(s).

Method for producing isothiocyanate compound

A novel organic amine salt or salt with quaternary ammonium ion of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid having useful properties as a drug is provided. A novel organic amine or salt with quaternary ammonium ion of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid, a method for producing the organic amine salt or the salt with quaternary ammonium ion and a platelet increasing agent.

Organic amine salts of aminobenzoic acid derivatives and method for producing same

A compound represented by the formula (1): wherein A, B, R, L, R, L, L, Y, L, Rand X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 

3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators

To provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) from the corresponding amino compound having a carboxyl group(s). A method for producing an isothiocyanate compound which has a carboxyl group(s) and is represented by the formula (2). And the method comprises reacting an amino compound which has a carboxyl group(s) and is represented by the formula (1) (wherein A is e.g. a Caromatic hydrocarbon group or a Csaturated hydrocarbon group, and B is e.g. a single bond, a Caromatic hydrocarbon group or a Csaturated hydrocarbon group), in a solvent, with carbon disulfide (CS) and then with a halogen as a simple substance. 

Method for producing isothiocyanate compound having carboxyl group

The present invention provides compounds useful for prevention, treatment or alleviation of diseases against which activation of the thrombopoietin receptor is effective. A compound represented by the formula (1): wherein A, B, R, L, R, L, L, Y, L, Rand X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

Amide compound and thrombopoietin receptor activator

Compounds effective for preventing, treatment or improving diseases against which activation of the thrombopoietin receptor is effective are provided. A compound represented by the formula (I) (wherein R, R, R, L, L, X and Y are defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 

Hydrazide compounds and thrombopoietin receptor activators

A compound represented by the formula (I) (wherein R, R, Rand Rare as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 

Thiophene compounds and thrombopoietin receptor activators

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Funabashi, Japan

Satoshi Nakano