The Green Cross Corporation

Satoshi Morimoto

Yasuo Ueda

Yoshio Kagitani

Kenji Tanaka

Kazumasa Yokoyama

Tadakazu Suyama

Satoshi Funakoshi

Yusei Shiraga

Shirou Komeda

Kozi Munechika

Benzodiazepine derivative represented by the following general formula or pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 is --COR.sup.4 (R.sup.4 is a carboxylic acid residue) or an alkyl or aralkyl group (these groups have a substituent selected from a carboxyl group, an amino group and a cyano group), R.sup.2 is a lower alkyl group and R.sup.3 is a hydrogen atom or a lower alkyl group. The above compound is low in toxicity and has an antitumor activity.

1H-pyrrolo-[2,1-C][1,4]benzodiazepine-2-acrylamide compounds having

The drug such as antitumor agents or antibiotics can preferentially be carried to a morbid part, for example, injured tissue and tumor site by administering its complex with fibronectin combined through an oxidized dextran to repair the morbid part. The complex is prepared by reacting the drug, an oxidized dextran having a cleaved structure of aldohexopyranose ring, and fibronectin.

Fibronectin-dextran-drug complex and method of preparation thereof

Growing community of inventors

Nagaokakyo, Japan

Satoshi Morimoto