Olympus Corporation

Astellas Pharma Gmbh

Apollo Endosurgery, Inc.

Olympus Medical Systems Corporation

Other

Terumo Kabushiki Kaisha

Yamanouchi Pharmaceutical Company Ltd.

Pasricha, Pankaj Jay

Satoshi Miyamoto

Yoshio Onuki

Pankaj Jay Pasricha

Norio Onishi

Tetsuya Yamamoto

Sydney Sheung Chee Chung

Keita Suzuki

Sergey Veniaminovich Kantsevoy

Toshihiro Watanabe

Masayuki Iwasaka

Seijiro Akamatsu

Tetsuo Kiso

Takahiro Kuramochi

Junichi Kobayashi

Ryo Sato

Satoshi Aoki

Takayuki Suzuki

Koichi Kawashima

Yuji Sakamoto

Masahiro Ishikawa

Kazuhiro Ikegai

Hironori Harada

Norio Asai

Anthony Nicholas Kalloo

Noriko Ishikawa

Hiroshi Yamada

Tsutomu Okada

Yasuhito Kura

Koichi Yonezawa

Takayasu Mikkaichi

Noriyuki Kawano

Shotaro Takemoto

Masahiko Hayakawa

Yasushi Kinoshita

Tadashi Kousai

Takehiro Nishiie

Junichi Muramatsu

Shohei Shirakami

Kenji Negoro

Tatsuya Maruyama

Raifu Matsui

Akio Kamikawa

Koh Kimura

Shigeki Kunikawa

Shinya Nagashima

Shimpei Kawakami

Yohei Koganemaru

Ryo Mizoguchi

Junya Ohmori

Yuka Koizumi

Takenori Kimura

Kousuke Motai

Noritaka Hamada

Yasuyuki Kuroda

Makoto Kasai

Takashi Ogiyama

Shuichirou Kakimoto

Junichi Shishikura

Ryosuke Nakano

Keisuke Tamaki

[Problem] Provided is a compound having a positive allosteric modulating activity (PAM activity) on an &#x3b1;7 nicotinic acetylcholine receptor (&#x3b1;7 nACh receptor). [Means for Solution] The present inventors have studied on a PAM activity on an &#x3b1;7 nACh receptor, and they have found that a tetrahydrooxepinopyridine compound has a PAM activity on an &#x3b1;7 nACh receptor, thereby completing the present invention. The tetrahydrooxepinopyridine compound of the present invention has a PAM activity on an &#x3b1;7 nACh receptor and can be expected as an agent for preventing or treating dementia, cognitive impairment, schizophrenia, Alzheimer's disease, CIAS, negative symptoms of schizophrenia, inflammatory diseases, or pain.

Tetrahydrooxepinopyridine compound

A treatment device for endoscopic therapy of the present invention includes a suturing-ligating member having a distal end portion and a proximal end portion, that carries out at least one of suturing and ligation of biological tissue, a stopper provided to be movable forward or backward on an proximal end side of the suturing or ligating member, and stoppable by friction on the suturing-ligating member to maintain the biological tissue in a sutured or ligated state by the suturing-ligating member, and a suturing-ligation releasing member provided movable with relative to the suturing-ligating member to release the suturing-ligation state maintained by firctional stopping between the suturing-ligating member and the stopper by moving the releasing member to the proximal end portion side of the suturing-ligating member.

Medical treatment device for suturing or ligating tissue

A biological tissue is sutured or ligatured, a suture and ligature member such as a ligature wire is cut, and then a holding member is reliably recovered from the body. In a holding member of a medical ligature tool, a protrusion is disposed between distal lateral holes, and proximal lateral holes, so that it protrudes outward in a diameter direction thereof. On the other hand, a concave portion is formed in the inner periphery of a cutting member. When the cutting member is extended to cut a ligature wire, the concave portion is fitted to the protrusion to allow the holding member to engage the cutting member.

Medical suture and ligature instrument and medical suture and ligature tool

An endoscopic treatment systemof the present invention includes an overtubethat is inserted into the body of a patient. An endoscopeand a suturing deviceare inserted into the overtube. The overtubehas a long and flexible tube main body, and a chamberis provided at the distal end of the tube main body. The chamberhas a lateral holeformed on the lateral surface thereof. The width of the lateral holeis set such that a lesion can be drawn into the lateral holewhile preventing other organs on the periphery of the lesion from being drawn into the lateral hole

Pressing member, endoscopic treatment system, and endoscopic suturing device

A ligature device for medical treatment has an operating device that has a ligature tool for medical treatment fitted onto a distal end portion thereof. The operating device is provided with a cutting member that is able to move freely backwards and forwards and is used to cut a ligature wire of the ligature tool for medical treatment. A distal end side of the cutting member has an inclined end portion that is inclined relative to the direction of forward and backward movement, and a blade portion is provided in this inclined end portion.

Suture and ligature device for medical treatment

A ligature and suture device for medical application includes a distal end insertion portion, a needle body, a ligature tool, and an operation section. The operation section includes a housing that is provided in a base end portion of the distal end insertion portion, a puncture handle that is provided in the housing so as to be able to move freely backwards and forwards and that drives the needle body, a pressing handle that is provided in the housing so as to be able to move freely backwards and forwards and that drives a pressing member, a ligature tool operation unit that is provided in the housing so as to be able to move freely backwards and forwards and that drives a ligature sheath, and a ligature handle that is provided in the ligature tool operation unit so as to be able to move freely backwards and forwards and that drives an engaging portion.

Ligature and suture device for medical application, and ligaturing and suturing method for medical application

An endoscope system includes: an endoscope including an elongated insertion portion provided with a bendable bending portion, the insertion portion being inserted into a duodenum; and a first balloon to a fourth balloon for moving a one-side surface of a distal end portion located nearer to a distal end side than the bending portion in the insertion portion in parallel with respect to a field of view direction S of an objective lens which is a diameter direction of the insertion portion, separately from bending of the bending portion, the one-side surface being located in a circumferential direction along an insertion direction W of the insertion portion and parallel to a central axis P of the insertion portion.

Endoscope system, endoscope, supporting member, and method of using endoscope system

A medical apparatus including: a projecting member; an introducing sheath; an extrusion member inside the introducing sheath, at a proximal side of the projecting member and movable in an axial direction with respect to the introducing sheath; a cover sheath outside the introducing sheath, the introducing sheath being movable between a first and second position with respect to the cover sheath; an introducing sheath manipulating section at a proximal side of the introducing sheath; an extrusion member manipulating section at a proximal side of the extrusion member; a cover sheath manipulating section at a proximal side of the cover sheath; and a release member on the cover sheath manipulating section and/or the introducing sheath manipulating section to release a fixation between the extrusion member manipulating section and the introducing sheath manipulating section when the introducing sheath is disposed on the first or second position.

Apparatus for ligating/suturing living tissues and system for resecting/suturing living tissues

Anytime obtained is uniform crystal of N-(4-fluorophenyl)-N'-phenyl-N&#x2033;-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound A) and/or N,N&#x2032;-bis (4-fluorophenyl)-N&#x2033;-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound B) as a medicament or a starting material for the preparation of the medicament, and provided are a fumarate of the compound A and/or the compound B having excellent stability and a novel crystal thereof. A salt of the compound A and/or the compound B with fumaric acid enables uniform crystal to be anytime obtained, and thus, it is a compound that is very useful as a medicament or a starting material for the preparation of the medicament having excellent stability.

Salt of 1,3,5-triazine-2,4,6-triamine derivative

There is provided an endoscopic system. The system comprises a flexible endoscope insertable into a first tubular organ from a natural opening of a human body. The system further comprises an opening member which forms on a wall part of the first tubular organ an opening used to insert the endoscope into an abdominal cavity from the first tubular organ in the body, an anastomosing member which is able to anastomoses the first tubular organ with a second tubular organ in the abdominal cavity, and a cutting member with which the second tubular organ is able to be cut.

Anastomosis system

A medical ligating apparatus includes a medical ligating device having a member which is made of a flexible line and ligates living tissues, and a fixing member which is movably provided at the ligating member and fixes the living tissues in a ligated state, a manipulating device having a flexible sheath and a proximal manipulating section, and a cutting member for cutting the ligating member. The cutting member is provided on the manipulating device and is movably provided on the ligating member.

Medical ligating apparatus

Medical procedure tool

A medical treatment tool comprises: a flexible wire; a first wire holding member which holds the wire; a second wire holding member capable of holding the wire between itself and the first wire holding member; a first sheath which is provided in contact with a proximal side of the second wire holding member; a second sheath which is provided in a back-and-forth movable manner with respect to the first sheath; and a sheath operation portion which operates the second sheath. The first wire holding member and the second sheath have a connection device for connecting them to each other; the first wire holding member and the second wire holding member have a latching device which latches them to each other when holding the wire there between, and a cutting device which cuts the wire; and the second wire holding member has a connection releasing device which releases the connection of the connection device, when latched by the first wire holding member.

Medical treatment tool

Growing community of inventors

Tokyo, Japan

Satoshi Miyamoto