Kureha Chemical Industry Company, Limited

Kureha Kagaku Kogyo Kabushiki Kaisha

Satoshi Mitsuhashi

Kiro Asano

Tsuyoshi Saito

Fumio Tamura

Tadahiro Matsudaira

Naohiro Sonobe

Michihito Ise

Hisayuki Wada

Humio Tamura

Hideyuki Yamato

Kenji Bannai

Haruhisa Hayashi

Susumu Morimoto

An adsorbent for an oral administration, comprising a porous spherical carbonaceous substance wherein a diameter is 0.01 to 1 mm, a specific surface area determined by a BET method is 700 m /g or more, a volume of pores having a pore diameter of 20 to 15000 nm is from not less than 0.04 mL/g to less than 0.10 mL/g, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 1.00 meq/g, is disclosed.

Adsorbent for oral administration

The invention is drawn to a method for suppressing an immunoresponse in animals by administering an estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different.

Method for suppressing an immunoresponse with an estradiol

An estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different; a process for preparing the same, and a pharmaceutical composition containing the conjugate are described.

Estradiol derivative-chlorambucil conjugate, process for preparing the

Estradiol derivative-chlorambucil conjugate process for preparing the

Disclosed herein is an injection containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-{p-bis(2-chloroethyl)amino)phenyl }butanoyloxy]acetate, which has been known as an orally administrable anti-tumor substance, as an active ingredient and an ester of iodinated poppy oil fatty acid as a solvent.

Injection containing

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Saitama, Japan

Satoshi Mitsuhashi