Koninklijke Philips Corporation N.v.

University of Washington

General Electric Company

Nihon Medi-physics Company, Limited

Satoshi Minoshima

Frank O Thiele

Gopal Biligeri Avinash

Saad Ahmed Sirohey

Zhongmin Steve Lin

Ananth P Mohan

Kiyotaka Watanabe

Kazuhiro Nishikawa

Shuya Miki

A method for assessing a treatment in a trial includes obtaining images generated from image data acquired at different times during a trial time period for a same region of interest of a subject. The treatment is administered to the subject for the trial. The method further includes co-registering the images and mapping the co-registered images to a reference image representing the region of interest. The method further includes generating a trial image of the region of interest showing at least one of structural or functional physiological changes that occurred during the trial time period based on the mapped co-registered images, and displaying the trial image.

Image based clinical trial assessment

Methods and apparatus for determining brain cortical thickness are provided. One method includes determining an intensity profile at each of a plurality of cortical surface points of an imaged brain using brain tissue image data and calculating a cortical thickness based on a parametrically determined transition point of each intensity profile.

Methods and apparatus for determining brain cortical thickness

CPUreads out the bloodstream associated values of target voxel of subject's standardized brain bloodstream images (step S). CPUsorts the bloodstream associated values in descending order (step S). CPUrejects bloodstream associated values that are ranked top 10% and bottom 40% (step S). When the subjects are 20 for example, bloodstream associated values of highest 2 subjects and of lowest 8 subjects are rejected. CPUcalculates and stores mean value and standard deviation of remaining bloodstream associated values after the rejection (step S). CPUcalculates mean value and standard deviation of bloodstream associated values for each voxel as target voxel (steps S, S, Sand S). Then, the alternative normal brain database of brain bloodstream image is obtained.

Device for generating alternative of normal brain database

Growing community of inventors

Seattle, WA, United States of America

Satoshi Minoshima