Otsuka Pharmaceutical Company, Limited

Satoshi Matsuda

Shigekazu Fujita

Kuninori Tai

Yasuhiro Menjo

Keizo Kan

Hokuto Yamabe

Hideto Fujiwara

Kazuhiro Ohdachi

Tatsuya Urushima

Taiki Hanari

Masatoshi Takuwa

Michiaki Tominaga

Seiji Sato

Takao Nishi

Hitoshi Tone

Yohji Sakurai

Takashi Okamoto

Tae Fukushima

Motohiro Itotani

Toshio Shinohara

Naohide Kanemoto

Chiharu Matsumura

Jun-ichi Minamikawa

Akihiro Hashimoto

The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin Vand Vantagonisms, and medical uses thereof. In the formula, Ris optionally substituted Calkyl, etc.; L is &#x2014;C(&#x2550;O)&#x2014;NH&#x2014;, etc.; Ring Ais a hydrocarbon ring, etc.; Ring Ais a hydrocarbon ring, etc.; and each of Rings Aand Amay have at least one substituent.

Benzazepine derivatives

The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin Vand Vantagonisms, and medical uses thereof. In the formula, Ris optionally substituted Calkyl, etc.; L is &#x2014;C(&#x2550;O)&#x2014;NH&#x2014;, etc.; Ring Ais a hydrocarbon ring, etc.; Ring Ais a hydrocarbon ring, etc.; and each of Rings Aand Amay have at least one substituent. 

This invention relates to a cyanotriazole compound represented by the formula (1): wherein each symbols are defined in the specification, or a salt thereof. The compound or a salt thereof stimulates the citric acid cycle activity and/or improves hyperglycemia with less side effects, and excellent safety, and therefore, it is useful for treating and/or preventing diseases or disorders on which citric acid cycle activation and/or improvement of hyperglycemia has a prophylactic and/or therapeutic effect, for example, diabetes, impaired glucose tolerance, insulin resistance, diabetic complications, obesity, dyslipidemia, hepatic steatosis, atherosclerosis and/or cardiovascular disease, as well as diseases or disorders that would benefit from stimulating energy expenditure.

Cyanotriazole compounds

An object of the present invention is to provide a commercially advantageous process for preparing a fluoro benzoic acid. The process according to the present invention comprises either alkylating a fluoro benzoic acid of the formula

Processes for the preparation of fluorinated benzoic acids

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Osaka, Japan

Satoshi Matsuda