Banyu Pharmaceutical Co. Ltd

Satoshi Mashiko

Hisashi Iwaasa

Hideki Sano

Akio Kanatani

Akane Ishihara

Kazuhiko Takahashi

Hiraku Itadani

Hidehito Kotani

Hiromitsu Araki

There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for functional analysis of the GPR103 genes and proteins and for the compound evaluation. The nucleic acids or proteins having the sequences listed as SEQ ID NOS: 1 to 4 provide non-human primate or rat GPR103 genes and proteins and information based on the genes and proteins. The genes and proteins can be used for evaluation of compounds. The nucleic acids or proteins having the sequence listed as SEQ ID NO: 5 or 6 provide a GPR103 ligand.

Nucleic acid encoding monkey QRFP

In the examination of obesity or leanness, the examination is based on the expression level of the MCP-1 gene or the MCP-1 protein in a tissue or cell analyte, or on the polymorphism in the gene. In the evaluation of compounds, including screening for therapeutic agents for obesity or leanness, the properties of the MCP-1 gene or the MCP-1 protein are utilized to carry out the evaluation.

Method for examining obesity or leanness

Nucleic acid encoding monkey Gpr103

Growing community of inventors

Tsukuba, Japan

Satoshi Mashiko