Jsr Corporation

Satoshi Katayose

Mitsuhiro Murata

Kouji Tamori

Kiyoshi Kasai

Tetsuo Fukuta

Mikio Hikata

Masaru Ueno

Kejun Fan

Kinji Yamada

Toshihiro Ogawa

Masayuki Takahashi

Eiji Takamoto

Ichiro Ozaki

Ichirou Ozaki

Masaaki Kitajima

Toru Masukawa

A process for producing carrier polymer particles comprising covering the surface of organic polymer particles having a particle diameter of 0.1 to 20 micrometers with a saccharide by chemically bonding the organic polymers and the saccharide.

Carrier polymer particle, process for producing the same, magnetic particle for specific trapping, and process for producing the same

The organic polymer particles comprise a carboxyl group and 2,3-dihydroxypropyl group, and the magnetic particles for diagnostics comprise fine magnetic material particles and a polymer part containing a hydrophilic polymer part and a crosslinked polymer part, a dry coating film obtained from a water dispersion thereof having a contact angle with water of 5&#xb0; to 60&#xb0;. The process for producing the carboxyl group-containing particles comprises a step of producing an ester bond by reacting a hydroxyl group in organic polymer particles having the hydroxyl group with a carboxylic anhydride. The organic polymer particles comprise a hydroxyl group originating from a 2,3-dihydroxypropyl group and a polyoxyethylene group.

Organic polymer particles and process for producing the same, magnetic particles for diagnostics, carboxyl group-containing particles and process for producing the same, and probe-bound particles and process for producing the same

A method for dissociating avidin or streptavidin efficiently from a biotin derivative, thereby making it possible to isolate a target material efficiently under a mild condition in a short period, and a dissociation agent for use thereof, are provided. The method for dissociating avidin or streptavidin from a biotin derivative, includes mixing a combination of avidin or streptavidin with desthiobiotin with a water-soluble polymer to which biotin or a derivative thereof is bound.

Dissociation method and dissociation agent for avidin and biotin derivatives

Magnetic particles comprising a group shown by the following formula (1): wherein Rand Rindividually represent a hydroxyl group, a group shown by the following formula (2), or a group shown by the following formula (3), provided that Rand Rare not both hydrogen atoms, wherein Rrepresents an a linear, branched, or cyclic alkylene group having 2 to 6 carbon atoms or an arylene group, and wherein Ris a hydrogen atom or an alkyl group.

Magnetic particles comprising an organic polymer layer and method for producing the same

A process of producing particles for diagnostic reagent, including forming a matrix particle by mixing a nuclear particle having a CV value of 20% or less and a magnetic substance containing at least one of FeOand FeOand giving a shear force to the mixture to adsorb the magnetic substance on the surface of the nuclear particles; and polymerizing a polymerizable monomer in the presence of said matrix particle to form a polymer layer on the magnetic substance layer.

Process for producing particles for diagnostic reagent

A process of producing particles for diagnostic reagent, including a step of polymerizing a polymerizable monomer in the presence of a matrix particle having a magnetic substance layer containing at least one of Fe O and Fe O on the surface thereof and having a mean particle size of 0.4-200 &mgr;m to form a polymer layer on the magnetic substance layer.

A particle for a diagnostic agent, which comprises a polymer particle comprising (A) from 20 to 100% by weight of a structural unit derived from at least one of acrylate having an aliphatic hydrocarbon group and methacrylate having an aliphatic hydrocarbon group, (B) from 0 to 10% by weight of a structural unit derived from unsaturated carboxylic acid, and (C) from 0 to 80% by weight of a structural unit derived from a vinyl monomer copolymerizable with the acrylate, methacrylate and unsaturated carboxylic acid, and a turbidmetric immunoassay using the same.

Growing community of inventors

Tsukubamirai, Japan

Satoshi Katayose