Pola Chemical Industries, Inc.

Satoshi Ichinomiya

Takayuki Namiki

Naoki Hiyama

Masashi Tamai

Masayuki Yuasa

Yukio Kawazu

Kenichi Kishii

Tomoaki Yahiro

Takako Takakuwa

Mayumi Sugio

Mariko Harada

Norio Funayama

Kyoko Taneda

Makoto Kimura

Masaki Mitani

Yoshio Kitada

Takao Hattori

Hideo Kuroda

Michi Otiai

Midori Oyobikawa

Biphenyl derivatives represented by the following formula (1): wherein Rrepresents a Calkyl group, Rrepresents a substituted or unsubstituted aromatic hydrocarbon, or cycloalkyl group, Rrepresents a tetrazolyl group, &#x2014;NHCOCF, &#x2014;NHSOCFor &#x2014;SONHCONHRin which Rrepresents a substituted or unsubstituted aromatic hydrocarbon group, and Z represents a single bond, a Calkylene group or &#x2014;SONH&#x2014;, and salts thereof; and ACAT inhibitors and medicines containing them as active ingredients. The compounds according to the present invention possess excellent ACAT inhibitory activities, and are useful as preventives and/or therapeutics for diseases cased by the enhancement of ACAT activity, for example, hypercholesterolemia, atherosclerosis and the like.

Biphenyl derivatives

Compound, polymer prepared from the compound, and composition comprising the polymer

The invention relates to a therapeutic and preventive medicament for respiratory diseases, comprising, as an active ingredient, a compound represented by the general formula (1):

Pyrrolo&lsqb;3,2-e&rsqb;pyrazolo&lsqb;1,5-a&rsqb;pyrimidine remedies/preventives for respiratory diseases

The invention relates to compounds represented by the following general formula (1): ##STR1## wherein R.sup.1 represents an alkyl group, R.sup.2 represents an amino group, alkyl group or the like, and R.sup.3 represents a nitro group, amino group, heterocyclic group, alkylsulfonylamino group or the like, or salts thereof, medicines comprising such a compound, a preparation process of the compounds, and intermediates useful for preparation thereof. The compounds (1) are useful for the prevention and treatment of a respiratory disease.

Pyrrolopyrazolopyrimidine compound and medicine comprising the same as

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Yokohama, Japan

Satoshi Ichinomiya