Hisamitsu Pharmaceutical Company, Inc.

Satoshi Amano

Natsumi Kase

Tomohiro Shinoda

Tetsuro Tateishi

Takashi Yasukochi

Yuka Takagi

Atsushi Sonobe

Naoyuki Uchida

Hidekazu Kuma

Arata Toshimitsu

Masaki Yukuhiro

Kumi Morimoto

Takao Kurokawa

Akio Takeuchi

Sachiko Honma

Akira Shuto

Junya Horiuchi

Keita Mori

Makoto Suzuki

A ropinirole-containing patch comprising a backing layer and an adhesive agent layer, wherein

Ropinirole-containing patch and method for improving skin permeability of ropinirole

An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan δ) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.

Asenapine-containing adhesive patch

The present invention provides a patch comprising a backing, and an adhesive layer on the backing, wherein the adhesive layer contains at least one drug selected from the group consisting of oxybutynin and a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive base, and diflucortolone valerate, and the content of the diflucortolone valerate is 0.0007 to 0.05% by mass based on the total mass of the adhesive layer.

Pharmaceutical patch

The present invention provides a patch comprising a backing and an adhesive layer laminated on one side of the backing, wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine.

Asenapine-containing patch

A transdermal preparation comprising a multivalent metal chloride, a basic drug having an amino group, and an ester group-containing base material, is useful because of its excellent drug content stability.

Transdermal preparation

By providing a non-liquid drug reservoir layerhaving first and second principal surfaces and containing a drug and a polymer that is to be a base, a drug permeation layerdisposed at the first principal surface side of the drug reservoir layerand being lower in permeability of the drug than the drug reservoir layer, and a first backingwith a bending resistance of 10 to 80 mm that is formed so as to cover a side surface of the drug reservoir layer, skin irritation can be reduced.

A transdermal absorption preparation having a support and a pressure-sensitive adhesive layer consisting of multiple layers, wherein the pressure-sensitive adhesive layer comprises a drug-retaining layer containing a drug and an acrylic pressure-sensitive adhesive and a skin adhesion layer containing a styrene-isoprene-styrene block copolymer. This preparation can continuously release bisoprolol at a constant concentration. Moreover, it can be easily produced.

Transdermal absorption preparation

Provided is a transdermal preparation, which is capable of long-term (1-day to 7-day) release of a basic drug from a preparation, continuously and at a consistent concentration; shows little reduction over time in the drug content, even if multiple drugs are contained in the preparation; and is produced by a simple process. The transdermal preparation comprises a substrate, and an adhesive layer containing a basic drug and a water-soluble polymer.

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Tsukuba, Japan

Satoshi Amano